{"id":"W3214353354","doi":"10.1093/ecco-jcc/jjab075.023","title":"OP24 Efficacy and safety of upadacitinib induction therapy in patients with Moderately to Severely Active Ulcerative Colitis: Results from the phase 3 U-ACHIEVE study","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Medicine; Ulcerative colitis; Clinical endpoint; Internal medicine; Gastroenterology; Clinical trial; Adverse effect; Randomized controlled trial; Placebo; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002006471,0.0006028808,0.001671904,0.0001955678,0.000276372,0.0008989135,0.0004238627,0.0006723669,0.002001791],"category_scores_gemma":[0.001338937,0.0001892513,0.001402277,0.0003691225,0.0003686188,0.0004517895,0.0003570052,0.001359349,0.0003290278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587659,"about_ca_system_score_gemma":0.0006805644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780479,"about_ca_topic_score_gemma":0.000795249,"domain_scores_codex":[0.9992613,0.0003876803,0.00005772403,0.00009420461,0.0001105393,0.00008841151],"domain_scores_gemma":[0.9992223,0.0002030191,0.0002494022,0.00005970395,0.00008480773,0.0001807531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6815023,0.01371759,0.02561539,0.003931871,0.006778949,0.0003409566,0.0002362586,0.002753744,0.03187669,0.0004371791,0.01098405,0.221825],"study_design_scores_gemma":[0.3765496,0.410466,0.1688165,0.0005422784,0.008487039,0.001238465,0.0002205834,0.003155309,0.01318513,0.0008228854,0.01635282,0.0001633938],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761653,0.01688651,0.0006875316,0.0004446446,0.00008783027,0.0007967619,0.002163781,0.00009433675,0.002673174],"genre_scores_gemma":[0.9939097,0.002027101,0.0005863835,0.0004730426,0.0001072938,0.0004966977,0.001748201,0.00001310554,0.0006384041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006471,"threshold_uncertainty_score":0.01061136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217801579624506,"score_gpt":0.2644544305463819,"score_spread":0.2522764147501368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}