{"id":"W3214359021","doi":"10.1016/j.ymthe.2021.10.025","title":"Eliminating Panglossian thinking in development of AAV therapeutics","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"Bayer Fund; Takeda Pharmaceutical Company; Takeda Pharmaceuticals U.S.A.; Novo Nordisk; Sanofi; Bayer; National Headache Foundation; National Hemophilia Foundation","keywords":"Food and drug administration; Advisory committee; Vector (molecular biology); Genetic enhancement; Medicine; Toxicity; Gene transfer; Genome; Gene; Virology; Biotechnology; Biology; Pharmacology; Political science; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004716699,0.0001770328,0.0001895767,0.00008349327,0.00008176277,0.00002661976,0.0002975869,0.0001400275,0.00004135927],"category_scores_gemma":[0.00002404716,0.0001789143,0.00009780684,0.0002803846,0.00005720176,0.000003167478,0.0001021164,0.0001434432,0.000005479599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003016947,"about_ca_system_score_gemma":0.0003656542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004077767,"about_ca_topic_score_gemma":0.0001026329,"domain_scores_codex":[0.9984286,0.0002096812,0.0003264656,0.0003661613,0.0003326571,0.000336446],"domain_scores_gemma":[0.9992408,0.00001320386,0.0000817508,0.000470154,0.0001436414,0.00005044045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003034844,0.0001433481,0.0009803695,0.00001175627,0.0001051869,0.00003631621,0.0006310568,0.00008031134,0.9001114,0.00006131293,0.000004053755,0.09753144],"study_design_scores_gemma":[0.001016079,0.0003879197,0.00134003,0.00002944815,0.000003068573,0.000006884846,0.0002087804,0.00003499668,0.9919653,0.0002472427,0.0045657,0.0001945294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896172,0.007080389,0.002020546,0.0002200601,0.0000455415,0.0001654047,0.000002440531,0.00001026221,0.0008381484],"genre_scores_gemma":[0.9927723,0.000522244,0.005584249,0.0008253039,0.00003551483,0.00002697317,0.00006265671,0.00004689491,0.0001239035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09733691,"threshold_uncertainty_score":0.7295912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927846685387006,"score_gpt":0.3159479862907282,"score_spread":0.2866695194368581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}