{"id":"W3214359021","doi":"10.1016/j.ymthe.2021.10.025","title":"Eliminating Panglossian thinking in development of AAV therapeutics","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"Bayer Fund; Takeda Pharmaceutical Company; Takeda Pharmaceuticals U.S.A.; Novo Nordisk; Sanofi; Bayer; National Headache Foundation; National Hemophilia Foundation","keywords":"Food and drug administration; Advisory committee; Vector (molecular biology); Genetic enhancement; Medicine; Toxicity; Gene transfer; Genome; Gene; Virology; Biotechnology; Biology; Pharmacology; Political science; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005601326,0.000392707,0.0003214077,0.000568409,0.0009418483,0.002230589,0.0005140956,0.001086944,0.003322073],"category_scores_gemma":[0.003419992,0.0002074845,0.00018163,0.0002683598,0.009160884,0.002218017,0.001608098,0.003837949,0.0005777233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002579504,"about_ca_system_score_gemma":0.003842885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719565,"about_ca_topic_score_gemma":0.004791573,"domain_scores_codex":[0.9982045,0.0008745985,0.00006732503,0.0001401852,0.0005933019,0.0001200336],"domain_scores_gemma":[0.9984797,0.0008674626,0.0001524736,0.0001204674,0.0002593982,0.0001206376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003473833,0.0001238504,0.001720528,0.0006264303,0.00004042264,0.0004236194,0.005152529,0.0007368095,0.02865808,0.7194409,0.007101815,0.2356276],"study_design_scores_gemma":[0.0001456994,0.0008874654,0.002157218,0.0008824607,0.0001219201,0.002175378,0.002503067,0.001895487,0.0530611,0.3500587,0.5860335,0.00007806624],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2144302,0.120256,0.1770352,0.1343395,0.005842604,0.0002224347,0.0001009768,0.0008133523,0.3469597],"genre_scores_gemma":[0.8438735,0.04070537,0.06169298,0.02129372,0.0009611013,0.0002055867,0.0000331807,0.0002453029,0.03098925],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005601326,"threshold_uncertainty_score":0.02962303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927846685387006,"score_gpt":0.3159479862907282,"score_spread":0.2866695194368581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}