{"id":"W3214369695","doi":"10.1111/imm.13429","title":"Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity","year":2021,"lang":"en","type":"article","venue":"Immunology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Engineering and Physical Sciences Research Council; European Commission; Seventh Framework Programme; Department of Health and Social Care","keywords":"DNA vaccination; Biology; Immunogenicity; Antigen; Immune system; Transgene; Molecular biology; Immunology; Cell biology; Gene; Genetics; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464331,0.0002460362,0.0003040244,0.0000556204,0.0001895933,0.00003737426,0.0003108974,0.0002605799,0.0001224911],"category_scores_gemma":[0.00007408295,0.0002095449,0.0001076555,0.0001448773,0.00007625853,0.000008614441,0.0002981815,0.0002105327,0.00001328067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001159945,"about_ca_system_score_gemma":0.0001441145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003360813,"about_ca_topic_score_gemma":0.00001013958,"domain_scores_codex":[0.9984614,0.0001484203,0.0002811621,0.0005538142,0.0001251712,0.0004300889],"domain_scores_gemma":[0.9989635,0.00002283053,0.0001453618,0.0006263751,0.0001837241,0.00005822579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003414853,0.0001028795,0.0005586592,0.00001100166,0.0001024464,0.00004498317,0.00009017448,0.00004401013,0.9963838,0.00002680796,0.0002144285,0.002079301],"study_design_scores_gemma":[0.001599503,0.0001638486,0.002221102,0.00003846995,0.00004386456,0.0002228874,0.0003496778,0.000009429652,0.97806,0.00002267491,0.01699626,0.0002722997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701956,0.02753007,0.0005875115,0.0001118354,0.0005274721,0.00008308353,0.00001113405,0.00003294251,0.000920355],"genre_scores_gemma":[0.9953111,0.001183597,0.001399649,0.0001950417,0.0004574222,0.00002286838,0.0001403267,0.00004046728,0.001249558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02634647,"threshold_uncertainty_score":0.8544993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600924571048641,"score_gpt":0.2165721760521088,"score_spread":0.2109712514810602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}