{"id":"W3214369695","doi":"10.1111/imm.13429","title":"Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity","year":2021,"lang":"en","type":"article","venue":"Immunology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Engineering and Physical Sciences Research Council; European Commission; Seventh Framework Programme; Department of Health and Social Care","keywords":"DNA vaccination; Biology; Immunogenicity; Antigen; Immune system; Transgene; Molecular biology; Immunology; Cell biology; Gene; Genetics; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963675,0.0004916523,0.0004020052,0.0002149675,0.000122797,0.0003255466,0.0002653709,0.000461092,0.0008741394],"category_scores_gemma":[0.0001663411,0.0001354831,0.0002070775,0.0001346074,0.0003109329,0.0003152568,0.0001548609,0.0009727048,0.0003463025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004897936,"about_ca_system_score_gemma":0.000342551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000621471,"about_ca_topic_score_gemma":0.0009362462,"domain_scores_codex":[0.9998122,0.00002527308,0.00001197297,0.00003570938,0.00004644771,0.00006851021],"domain_scores_gemma":[0.9998873,0.00003114051,0.00003466806,0.00001156013,0.0000118219,0.00002350995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009661847,0.00003547717,0.00004070403,0.0000207667,0.000002470787,0.00001164415,0.000007378949,0.00008164198,0.9984115,0.00004510947,0.00002211186,0.0012244],"study_design_scores_gemma":[0.00002516833,0.0007346084,0.0008381095,0.000004354896,0.00001297161,0.00007637677,0.000008660431,0.0006585434,0.9962646,0.00003328997,0.001340235,0.000002986481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935324,0.002031164,0.003123655,0.0001190317,0.00003436996,0.00004147239,0.0001212167,0.0001046046,0.0008920871],"genre_scores_gemma":[0.9944031,0.001004784,0.002443499,0.00004966122,0.00001710077,0.0000558446,0.0001663435,0.0000205164,0.001839315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008741394,"threshold_uncertainty_score":0.003553689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600924571048641,"score_gpt":0.2165721760521088,"score_spread":0.2109712514810602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}