{"id":"W3214376594","doi":"10.1182/blood-2021-152987","title":"Immune Repertoire Analysis of Multiple Myeloma Research Samples Using NGS Characterization of Multiple B Cell Receptors in a Single Reaction","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Biology; Immunoglobulin heavy chain; Chronic lymphocytic leukemia; Immunoglobulin light chain; breakpoint cluster region; B-cell receptor; Molecular biology; Multiplex ligation-dependent probe amplification; B cell; IGHV@; Gene rearrangement; Genetics; Plasma cell neoplasm; Computational biology; Antibody; Gene; Multiple myeloma; Leukemia; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018154,0.0006382145,0.0003648216,0.001655692,0.0003726093,0.000538522,0.0003472192,0.00058644,0.002890788],"category_scores_gemma":[0.000636813,0.0002421142,0.0003750944,0.0007755192,0.0003792748,0.0002010011,0.0004289306,0.0004600997,0.001269664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143097,"about_ca_system_score_gemma":0.0003317486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005705886,"about_ca_topic_score_gemma":0.001099155,"domain_scores_codex":[0.9988819,0.0001360274,0.0001088162,0.0004024288,0.0003515564,0.0001192687],"domain_scores_gemma":[0.9995436,0.000143193,0.00007389018,0.00006141012,0.000127773,0.00005018907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009473339,0.00002834274,0.003609498,0.0001185198,0.00001573244,0.0001120354,0.0001029228,0.0001510366,0.9856618,0.00009931952,0.000100838,0.009905264],"study_design_scores_gemma":[0.00002034986,0.0003444051,0.02384906,0.00007396965,0.00008181465,0.0008396088,0.0001863193,0.004154191,0.9622984,0.0004564434,0.007675206,0.00002031399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7285377,0.004408855,0.2511747,0.0003364941,0.0001338473,0.0009561462,0.003146289,0.00205869,0.009247298],"genre_scores_gemma":[0.6555699,0.002148128,0.3307798,0.000525918,0.0000693266,0.00114233,0.003477374,0.0002902108,0.005997046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002890788,"threshold_uncertainty_score":0.009670675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0800012272170901,"score_gpt":0.331695166973778,"score_spread":0.251693939756688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}