{"id":"W3214400070","doi":"10.1182/blood-2021-146987","title":"Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Patients with Lower-Risk Myelodysplastic Syndromes","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Tolerability; Medicine; Myelodysplastic syndromes; Splicing factor; Internal medicine; Pharmacodynamics; Protein arginine methyltransferase 5; International Prognostic Scoring System; Pharmacology; Oncology; Methyltransferase; Cancer research; Gastroenterology; Adverse effect; Pharmacokinetics; RNA splicing; Biology; Methylation; Gene; Bone marrow; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009617036,0.0001710071,0.0002300158,0.00007623357,0.00003171384,0.00001003838,0.00008004727,0.0001100047,0.0000217206],"category_scores_gemma":[0.00007512598,0.0001601924,0.00004730689,0.0003028232,0.00003627051,0.000005644279,0.0000401692,0.0001160847,0.000001671638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000131135,"about_ca_system_score_gemma":0.0001470945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000294672,"about_ca_topic_score_gemma":0.0002643359,"domain_scores_codex":[0.9987959,0.0001205387,0.0002728452,0.0003977225,0.0002263543,0.000186699],"domain_scores_gemma":[0.9993145,0.000009933675,0.0001046515,0.0003540542,0.0001577432,0.00005908535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002694813,0.04016978,0.2088383,0.0001335422,0.0009439844,0.0001103969,0.0005037626,0.001319234,0.7412302,0.000005424048,0.00005027537,0.004000241],"study_design_scores_gemma":[0.05141252,0.01381781,0.06376834,0.0001476158,0.0003506456,0.00001116947,0.0001699092,0.00003997148,0.8697152,0.000008977387,0.0001744243,0.0003834001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986455,0.0003242552,0.0001450661,0.00001392761,0.00006944532,0.0007157795,0.00004835166,0.000009004316,0.00002870983],"genre_scores_gemma":[0.999395,0.00001550246,0.0002094209,0.000004563782,0.00005272594,0.00006920189,0.0001466872,0.00002814546,0.00007881945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1450699,"threshold_uncertainty_score":0.6532456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004577758031000481,"score_gpt":0.2222939556325588,"score_spread":0.2177161976015583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}