{"id":"W3214400070","doi":"10.1182/blood-2021-146987","title":"Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Patients with Lower-Risk Myelodysplastic Syndromes","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Tolerability; Medicine; Myelodysplastic syndromes; Splicing factor; Internal medicine; Pharmacodynamics; Protein arginine methyltransferase 5; International Prognostic Scoring System; Pharmacology; Oncology; Methyltransferase; Cancer research; Gastroenterology; Adverse effect; Pharmacokinetics; RNA splicing; Biology; Methylation; Gene; Bone marrow; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068819,0.001377944,0.001675663,0.0005184848,0.000470959,0.0008070698,0.0008350521,0.0009616031,0.00249682],"category_scores_gemma":[0.0005809233,0.0005663643,0.0008851599,0.0003032925,0.0006727893,0.000548531,0.0003240893,0.002419711,0.0007193918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005558411,"about_ca_system_score_gemma":0.001337756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044718,"about_ca_topic_score_gemma":0.001603402,"domain_scores_codex":[0.9996703,0.0001445618,0.00001528235,0.00006433638,0.00003188708,0.0000737109],"domain_scores_gemma":[0.9995577,0.00006086966,0.00008103653,0.00004004566,0.000043012,0.0002173665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.383389,0.1716201,0.01541885,0.0009853527,0.00134839,0.001038612,0.0008276357,0.009735693,0.2504876,0.0007696857,0.006694889,0.1576843],"study_design_scores_gemma":[0.1882477,0.7817037,0.01180217,0.00002650042,0.0003340364,0.0004930958,0.00006070312,0.001562276,0.01203669,0.0002244272,0.003476357,0.00003242366],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993379,0.0007883746,0.0006266118,0.0002267686,0.00006581657,0.002921775,0.0007587775,0.00008753722,0.001145204],"genre_scores_gemma":[0.9874623,0.001000376,0.002462509,0.0005013967,0.0001228368,0.003462276,0.001794434,0.0000347381,0.003159076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249682,"threshold_uncertainty_score":0.008352637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004577758031000481,"score_gpt":0.2222939556325588,"score_spread":0.2177161976015583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}