{"id":"W3214432495","doi":"10.1182/blood-2021-145773","title":"A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Entospletinib in Combination with Intensive Induction and Consolidation Chemotherapy in Adults with Newly Diagnosed <i>N</i> <i>ucleophosmin 1-</i>mutated Acute Myeloid Leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cytarabine; Idarubicin; Medicine; Internal medicine; Myeloid leukemia; Oncology; Induction chemotherapy; Myeloid; Daunorubicin; Mitoxantrone; Gastroenterology; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001371013,0.001365469,0.003187231,0.0003147985,0.0004626087,0.0008911429,0.0009312428,0.00164621,0.005319608],"category_scores_gemma":[0.001185565,0.0005566242,0.001216218,0.0003655006,0.001298424,0.0009917959,0.0003366351,0.003259186,0.0009491507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005845329,"about_ca_system_score_gemma":0.001233773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004882938,"about_ca_topic_score_gemma":0.001391078,"domain_scores_codex":[0.9995453,0.0002182818,0.00002765453,0.00009798234,0.00003716242,0.00007358609],"domain_scores_gemma":[0.9990878,0.0001940045,0.0001922936,0.00008471177,0.00007323575,0.000367889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9732863,0.01136982,0.0004589659,0.0004138772,0.0005477153,0.00002940677,0.00003144388,0.0001898665,0.003353875,0.00006572645,0.0004876714,0.009765225],"study_design_scores_gemma":[0.9024255,0.095109,0.001240931,0.0000181582,0.0002227247,0.00002463717,0.00001166124,0.0002642518,0.0002799013,0.00006095229,0.0003335276,0.000008759932],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884347,0.003121203,0.0007035463,0.0004806404,0.0004591199,0.00445649,0.0007667547,0.000122445,0.00145521],"genre_scores_gemma":[0.985437,0.001787137,0.001828694,0.001368375,0.0004301981,0.00627267,0.0009547984,0.00002136109,0.001899761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005319608,"threshold_uncertainty_score":0.0177958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767328303820485,"score_gpt":0.3028552899997753,"score_spread":0.2851820069615704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}