{"id":"W3214473897","doi":"10.1182/blood-2021-150371","title":"Safety and Efficacy of Cusatuzumab in Combination with Venetoclax and Azacitidine (CVA) in Patients with Previously Untreated Acute Myeloid Leukemia (AML) Who Are Not Eligible for Intensive Chemotherapy; An Open-Label, Multicenter, Phase 1b Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Venetoclax; Azacitidine; Medicine; Myeloid leukemia; Chemotherapy regimen; Internal medicine; Oncology; Leukemia; Chemotherapy; Cytarabine; Myeloid; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001330154,0.0008782152,0.001584926,0.0004151915,0.0004015907,0.001002971,0.0006270425,0.0009936491,0.001430429],"category_scores_gemma":[0.0009669897,0.0004315031,0.0009081989,0.0003706104,0.0007784732,0.0007944786,0.0002499105,0.002289409,0.0004051512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007733101,"about_ca_system_score_gemma":0.0008558285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005563548,"about_ca_topic_score_gemma":0.0009514023,"domain_scores_codex":[0.9994665,0.0002781033,0.00003091688,0.0001038837,0.00005120284,0.00006948599],"domain_scores_gemma":[0.9991078,0.0001890753,0.0002294832,0.00007131793,0.0000465687,0.0003557305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7144274,0.08125847,0.02266138,0.0006577712,0.001708865,0.0004070783,0.0004660024,0.002884735,0.07726446,0.0002015212,0.001548422,0.09651398],"study_design_scores_gemma":[0.2564604,0.698119,0.03370282,0.00003595925,0.0006962024,0.0004660053,0.00008663556,0.001832973,0.006305799,0.000133128,0.002123955,0.00003711427],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977088,0.001173193,0.0001489917,0.0000750347,0.00002705439,0.0002711619,0.0001892001,0.00001810649,0.0003885861],"genre_scores_gemma":[0.9977939,0.0005209784,0.0003587728,0.00015738,0.00008649435,0.0002685301,0.0004278375,0.00000750113,0.0003785777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584926,"threshold_uncertainty_score":0.0070346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001569307206054,"score_gpt":0.3170874715154975,"score_spread":0.297071778443437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}