{"id":"W3214531966","doi":"10.1016/j.jcjd.2021.09.061","title":"Genetic Spectrum in a Canadian Cohort of Apparently Sporadic Pheochromocytomas and Paragangliomas (PPGLs): New Data on Multigene Panel Retesting Over Time","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Pheochromocytoma; Paraganglioma; Germline; Heritability; Cohort; Population; Germline mutation; Oncology; Internal medicine; Pathology; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007148815,0.0007298375,0.000498243,0.002192646,0.003177289,0.001433053,0.001578828,0.0007444712,0.002196167],"category_scores_gemma":[0.002739875,0.0005384717,0.0006798138,0.004515951,0.0008368176,0.0004871912,0.0008547828,0.0009643353,0.0003238018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01073289,"about_ca_system_score_gemma":0.01296179,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9750131,"about_ca_topic_score_gemma":0.9745778,"domain_scores_codex":[0.9985853,0.00005626483,0.00006710567,0.0003848455,0.0005476898,0.0003587606],"domain_scores_gemma":[0.9974054,0.0001428714,0.0003361918,0.000156038,0.001418198,0.00054121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001707925,0.00004290287,0.9913537,0.00001872187,0.0001059553,0.0007325914,0.0008492056,0.0001051582,0.001319095,0.0001169338,0.001404965,0.003779991],"study_design_scores_gemma":[0.000008716791,0.00002592054,0.9970115,0.00001062313,0.00006150767,0.0007194499,0.0005914182,0.0001588021,0.00008541572,0.00003998508,0.00126748,0.00001911279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918754,0.0005739047,0.0001624808,0.000253227,0.00002129878,0.00003235542,0.004947214,0.00001825816,0.002116001],"genre_scores_gemma":[0.9960046,0.0004536416,0.000255433,0.0001333022,0.000009988728,0.00001352979,0.002235951,0.00001470824,0.0008788271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02498692,"threshold_uncertainty_score":0.07787293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778270077818812,"score_gpt":0.2457903825084377,"score_spread":0.2180076817302495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}