{"id":"W3214531966","doi":"10.1016/j.jcjd.2021.09.061","title":"Genetic Spectrum in a Canadian Cohort of Apparently Sporadic Pheochromocytomas and Paragangliomas (PPGLs): New Data on Multigene Panel Retesting Over Time","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Pheochromocytoma; Paraganglioma; Germline; Heritability; Cohort; Population; Germline mutation; Oncology; Internal medicine; Pathology; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000381517,0.0002172235,0.0006309761,0.0006813164,0.0000702196,0.00003457675,0.0002591878,0.0001083414,0.0005319817],"category_scores_gemma":[0.0006186533,0.0002066648,0.00007613697,0.0005862109,0.0001268822,0.0001120322,0.00002789745,0.000348299,0.00001317393],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801448,"about_ca_system_score_gemma":0.007238214,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1426873,"about_ca_topic_score_gemma":0.5882896,"domain_scores_codex":[0.9980688,0.00006920796,0.0006105133,0.0003118688,0.0002603406,0.0006792602],"domain_scores_gemma":[0.9968538,0.0001337001,0.0002612288,0.0004702442,0.0001091996,0.002171823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001609587,0.0000317182,0.9722078,0.00007738548,0.000160877,0.02174787,0.000301698,0.00008159057,0.000681782,0.0000236118,0.002402314,0.002267204],"study_design_scores_gemma":[0.001495944,0.0002970759,0.9901097,0.0009044587,0.0001685714,0.002215811,0.00005648948,0.001155969,0.002500637,0.0001960388,0.0006854151,0.0002139173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924491,0.005693374,0.000001553239,0.0008277734,0.0001467103,0.0001713518,0.0001355034,0.000004613348,0.0005700191],"genre_scores_gemma":[0.9984277,0.00001274926,0.0005176257,0.0003894139,0.0003087156,8.75159e-7,0.0000718047,0.0000325711,0.0002385261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4456023,"threshold_uncertainty_score":0.9983898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778270077818812,"score_gpt":0.2457903825084377,"score_spread":0.2180076817302495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}