{"id":"W3214619569","doi":"10.1093/hmg/ddab330","title":"The F-box protein, FBXO7, is required to maintain chromosome stability in humans","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; F-box protein; Chromosome instability; Gene; Genetics; Genome instability; Carcinogenesis; Cell growth; Ubiquitin ligase; Cell biology; Cancer research; Chromosome; Ubiquitin; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009570926,0.0001704666,0.0001493275,0.0002526168,0.000161464,0.000224947,0.0001224243,0.000266699,0.0009746417],"category_scores_gemma":[0.0001712358,0.00007718518,0.0001076684,0.0001376536,0.000243854,0.00009139625,0.0001417372,0.0001861596,0.0003412306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969066,"about_ca_system_score_gemma":0.0002654542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000936132,"about_ca_topic_score_gemma":0.0006808116,"domain_scores_codex":[0.9999274,0.000009966582,0.000004780528,0.00002231309,0.00002523134,0.00001024705],"domain_scores_gemma":[0.9999433,0.000006508687,0.00002480855,0.00000380339,0.000008937375,0.00001268349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002951841,0.00003338938,0.01082275,0.00023914,0.00004614533,0.001862678,0.00006153993,0.0003754594,0.9397889,0.001934928,0.001675264,0.04286454],"study_design_scores_gemma":[0.0001058618,0.0008924256,0.3037907,0.0001715138,0.0002209766,0.02695699,0.0003215273,0.004343766,0.5151846,0.004212892,0.1437422,0.00005638404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579445,0.02294054,0.009763989,0.0008819827,0.00009338707,0.00004048945,0.00173973,0.0003150846,0.006280172],"genre_scores_gemma":[0.9867281,0.005044916,0.003017072,0.0001783006,0.00002481279,0.00002459048,0.0008444702,0.00001968332,0.00411801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009746417,"threshold_uncertainty_score":0.003260553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179766431406407,"score_gpt":0.2723806667747283,"score_spread":0.2505830024606643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}