{"id":"W3214630876","doi":"10.1161/circ.144.suppl_1.10357","title":"Abstract 10357: ARO-APOC3, an Investigational RNAi Therapeutic, Shows Similar Efficacy and Safety in Genetically Confirmed FCS and Non-FCS Participants with Severe Hypertriglyceridemia","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Hypertriglyceridemia; Internal medicine; Endocrinology; Apolipoprotein B; Gastroenterology; Triglyceride; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000242932,0.0001733421,0.0003110904,0.00006789725,0.00008435544,0.00004234593,0.00003412301,0.000140155,0.0001145129],"category_scores_gemma":[0.0001862773,0.0001500455,0.00002360269,0.0001850096,0.0001653477,0.0001865969,0.00001813835,0.0001754773,0.000004123216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002793115,"about_ca_system_score_gemma":0.0003284224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002806765,"about_ca_topic_score_gemma":0.00009271425,"domain_scores_codex":[0.9986777,0.00006709069,0.0003305453,0.0003872293,0.0002737627,0.0002637013],"domain_scores_gemma":[0.9991579,0.000138435,0.00007594932,0.0002326167,0.0001202199,0.0002748563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005783348,0.0002410944,0.9191406,0.000121006,0.00007693839,0.00003798357,0.001030252,0.001263097,0.05804363,0.0005259967,0.00002486607,0.0189162],"study_design_scores_gemma":[0.005202929,0.00005627959,0.9869958,0.00008177834,0.0001334797,0.00006132705,0.0002434911,0.005008527,0.0009794054,0.000493208,0.0005532489,0.0001905173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966945,0.0008035499,0.0002645718,0.001052469,0.0000612132,0.000418648,0.0000105812,0.00002690931,0.0006675413],"genre_scores_gemma":[0.9969933,0.0001681112,0.0009896777,0.001508983,0.0001198191,0.00001509823,0.0001647394,0.00002383259,0.00001644707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0678552,"threshold_uncertainty_score":0.6118677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341906434011473,"score_gpt":0.280206232651858,"score_spread":0.2460155892507107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}