{"id":"W3214630876","doi":"10.1161/circ.144.suppl_1.10357","title":"Abstract 10357: ARO-APOC3, an Investigational RNAi Therapeutic, Shows Similar Efficacy and Safety in Genetically Confirmed FCS and Non-FCS Participants with Severe Hypertriglyceridemia","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Hypertriglyceridemia; Internal medicine; Endocrinology; Apolipoprotein B; Gastroenterology; Triglyceride; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003238166,0.0003277155,0.0005083375,0.000190155,0.000148726,0.0002125624,0.0002504424,0.0005569474,0.004486557],"category_scores_gemma":[0.000295666,0.000103341,0.000369931,0.0001803163,0.0002836304,0.0002039525,0.0001228047,0.0007995337,0.0004512123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255704,"about_ca_system_score_gemma":0.0003239654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006735345,"about_ca_topic_score_gemma":0.001326497,"domain_scores_codex":[0.9999002,0.00003484824,0.000009597085,0.00001884188,0.00002178203,0.00001462591],"domain_scores_gemma":[0.9998418,0.00002928904,0.00005197018,0.00001534065,0.00001791636,0.00004372869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.143701,0.01405823,0.006714419,0.0007047295,0.00048016,0.0004666314,0.0001604674,0.0005014395,0.6826758,0.0002097822,0.00286145,0.1474658],"study_design_scores_gemma":[0.08037551,0.5469956,0.1057299,0.0001282703,0.001007739,0.003259435,0.0002110138,0.002866258,0.2453929,0.0001794054,0.0137973,0.00005668818],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964646,0.0009923708,0.0004165771,0.0001429954,0.00003174357,0.0001729321,0.0004266042,0.00008645486,0.001265684],"genre_scores_gemma":[0.9959269,0.0005590888,0.0009128846,0.0001648234,0.00002774692,0.0002205783,0.0008020325,0.00001351814,0.001372276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004486557,"threshold_uncertainty_score":0.01500905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341906434011473,"score_gpt":0.280206232651858,"score_spread":0.2460155892507107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}