{"id":"W3214655201","doi":"10.1101/2021.11.03.21265533","title":"Effect of the Neutralizing SARS-CoV-2 Antibody Sotrovimab in Preventing Progression of COVID-19: A Randomized Clinical Trial","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"Vir Biotechnology; GlaxoSmithKline","keywords":"Medicine; Placebo; Randomized controlled trial; Coronavirus disease 2019 (COVID-19); Clinical endpoint; Internal medicine; Clinical trial; Severity of illness; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Infectious disease (medical specialty); Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.02317017,0.0004990179,0.003669011,0.0004266422,0.00007746727,0.00005177246,0.0008264115,0.0007608691,0.000009687],"category_scores_gemma":[0.03448606,0.0003091749,0.00225664,0.0007068535,0.0007409126,0.00006132931,0.001543734,0.00220119,0.00000277157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587751,"about_ca_system_score_gemma":0.002812643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005567778,"about_ca_topic_score_gemma":0.00005229846,"domain_scores_codex":[0.9851812,0.009188205,0.002679906,0.001024113,0.001337184,0.0005894654],"domain_scores_gemma":[0.9904081,0.006344061,0.001429221,0.001491989,0.0002444651,0.00008219393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4865263,0.001078104,0.2719155,0.008027383,0.000494938,0.0002171989,0.0006342168,0.000004439005,0.2268497,0.00001998501,0.00002975853,0.004202562],"study_design_scores_gemma":[0.4868177,0.0009466821,0.001729209,0.00402544,0.0006311809,0.00001852378,0.00004499853,0.00114552,0.5036805,0.00009171513,0.0006346229,0.0002339098],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988346,0.00152674,0.0002575722,0.0005007817,0.001263386,0.007747142,0.000008300732,0.00005451591,0.0002955245],"genre_scores_gemma":[0.9967105,0.00007275512,0.0002313912,0.002067025,0.0003735921,0.0004509509,0.00001960515,0.00006509159,0.00000909697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2768308,"threshold_uncertainty_score":0.999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08906960352248401,"score_gpt":0.4873188389306667,"score_spread":0.3982492354081827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}