{"id":"W3214665950","doi":"10.1038/s41525-021-00256-y","title":"Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood","year":2021,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Wellcome Trust; Hartwell Foundation; Johns Hopkins University; U.S. Department of Health and Human Services","keywords":"DNA methylation; Epigenetics; DNA demethylation; Genetics; Biology; 5-Hydroxymethylcytosine; DNA; Chromatin; Methylation; CpG site; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004425731,0.0001504799,0.0002622576,0.0001345302,0.00004789308,0.000005553104,0.0001595843,0.0001742461,0.00008419972],"category_scores_gemma":[0.0003396359,0.0001440759,0.00005317702,0.0002752005,0.00006392342,0.000002529545,0.00009062389,0.0001176004,0.000007055085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002386072,"about_ca_system_score_gemma":0.00009929592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002877615,"about_ca_topic_score_gemma":0.0001018692,"domain_scores_codex":[0.9986686,0.00008991735,0.0004311782,0.0004013522,0.0001802498,0.0002287559],"domain_scores_gemma":[0.9992024,0.00002984166,0.0001134032,0.0004088919,0.0001465058,0.00009890147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001486353,0.00006777315,0.02121246,0.00003075142,0.00001204258,0.000008015519,0.0002793297,0.0005831881,0.9767633,0.00005394775,0.00007199813,0.0009023485],"study_design_scores_gemma":[0.001053915,0.000496226,0.1386534,0.00004151718,0.00004029719,0.000003856923,0.000134397,0.00001291889,0.8511754,0.0003840654,0.007830188,0.0001739107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860181,0.009174309,0.001368134,0.0005770464,0.0001155663,0.0001974845,0.00001149272,0.000005367056,0.002532534],"genre_scores_gemma":[0.9969445,0.0002644412,0.00105965,0.0003213699,0.0002463525,0.0000107942,0.0003064609,0.0000227161,0.0008236951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1255879,"threshold_uncertainty_score":0.5875245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118509026217796,"score_gpt":0.2651565304655102,"score_spread":0.2533056278437306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}