{"id":"W3214681333","doi":"10.1021/acs.jmedchem.1c01712","title":"Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Innate immune system; Microbiology; Antibiotics; Chemistry; Immune system; Biofilm; Bacteria; Peptide; Host (biology); Conjugate; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344595,0.0002570733,0.0002244773,0.000125777,0.00009161491,0.0002321377,0.0001034422,0.000341236,0.001451841],"category_scores_gemma":[0.0001317123,0.00008585284,0.0001083572,0.00007541105,0.0001823847,0.0002176969,0.0001756955,0.0004966548,0.0002596361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113069,"about_ca_system_score_gemma":0.0001448207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006331681,"about_ca_topic_score_gemma":0.0001000653,"domain_scores_codex":[0.9999298,0.00001737756,0.00000384185,0.00001365844,0.00001908978,0.00001629242],"domain_scores_gemma":[0.9999311,0.00001092167,0.00001925267,0.000006989826,0.000009628625,0.00002202489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000181051,0.00006404273,0.000187965,0.00004447509,0.000005310137,0.00005670123,0.000006475048,0.000136039,0.9917318,0.0001885076,0.0001241864,0.007273535],"study_design_scores_gemma":[0.00008948637,0.003083625,0.003704736,0.00001582468,0.00002299311,0.0006828207,0.00001565287,0.000997082,0.9833839,0.0001530342,0.007842047,0.00000878518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822986,0.005108035,0.0080182,0.0002969718,0.00009770253,0.00006891981,0.000164993,0.00008602883,0.003860477],"genre_scores_gemma":[0.9937168,0.001063393,0.003198816,0.0001395822,0.00002844497,0.00002516442,0.0001394282,0.00000740071,0.001681025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001451841,"threshold_uncertainty_score":0.004856944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008062822811004433,"score_gpt":0.2181022934375532,"score_spread":0.2100394706265488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}