{"id":"W3214681333","doi":"10.1021/acs.jmedchem.1c01712","title":"Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Innate immune system; Microbiology; Antibiotics; Chemistry; Immune system; Biofilm; Bacteria; Peptide; Host (biology); Conjugate; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007490793,0.0001971354,0.0003910304,0.00003962277,0.0002352968,0.00003943366,0.0001766478,0.0001880701,0.0008193873],"category_scores_gemma":[0.0005768411,0.0001312223,0.0001441323,0.00008876847,0.0006904768,0.00009213751,0.00010053,0.0006151931,0.00002095913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002989814,"about_ca_system_score_gemma":0.0002070498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001999575,"about_ca_topic_score_gemma":9.106996e-7,"domain_scores_codex":[0.9987726,0.000180359,0.0005170527,0.0001838222,0.00008487212,0.0002613324],"domain_scores_gemma":[0.9986283,0.0004630464,0.000423729,0.0001868076,0.0002451008,0.00005308278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001502095,0.00008417109,0.0007472994,0.00004687246,0.0003103833,0.0001392063,0.0002164022,0.000004949529,0.9925386,0.000008330381,0.004063968,0.0003377461],"study_design_scores_gemma":[0.001526751,0.0001376992,0.02763597,0.000304194,0.0001218672,0.007630529,0.001284869,0.000003268359,0.9507853,0.00002422012,0.01039647,0.0001488047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866973,0.009053132,0.00001556392,0.003462344,0.0004999361,0.00004223725,0.00003777154,0.000009819028,0.0001819542],"genre_scores_gemma":[0.9933658,0.00105364,0.000184449,0.0003916424,0.0002204524,5.044304e-7,0.00002696693,0.00001622556,0.004740338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04175322,"threshold_uncertainty_score":0.8971716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008062822811004433,"score_gpt":0.2181022934375532,"score_spread":0.2100394706265488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}