{"id":"W3214733033","doi":"10.1002/ctm2.577","title":"Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"Natural Science Foundation of Guizhou Province; National Natural Science Foundation of China","keywords":"Baicalein; Cancer research; Tamoxifen; Anaerobic glycolysis; Pharmacology; Apoptosis; Cancer cell; Breast cancer; Chemistry; Medicine; Cancer; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114842,0.0001458433,0.0003551949,0.00004056881,0.0001059335,0.000009081289,0.00003059382,0.0002046933,0.0001091685],"category_scores_gemma":[0.00009199919,0.0001277629,0.00009224143,0.0001347868,0.0004224106,0.00001236974,0.0000219004,0.000154035,4.327219e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005141632,"about_ca_system_score_gemma":0.000095152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000166163,"about_ca_topic_score_gemma":0.00009906526,"domain_scores_codex":[0.9985085,0.0001287902,0.0005217154,0.0004694985,0.0002164247,0.000155059],"domain_scores_gemma":[0.9992625,0.0001171353,0.0001257397,0.0001500094,0.0001899047,0.0001547569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006880648,0.00006948448,0.0004922682,0.00005440978,0.00008320484,0.000001950572,0.00005564492,0.00001107191,0.980781,0.00003104571,0.002861456,0.01487043],"study_design_scores_gemma":[0.01457648,0.000733498,0.09069204,0.0007504206,0.0007717891,0.00009783754,0.0002066348,0.000266708,0.8308079,0.001213687,0.05924951,0.0006335406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829879,0.009643463,0.002063143,0.00346412,0.001377871,0.0001482281,0.0002091734,0.000007182333,0.00009893472],"genre_scores_gemma":[0.9919047,0.003969522,0.0004487851,0.0002470062,0.00287049,0.000006891456,0.0002640763,0.00001408266,0.0002744597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1499731,"threshold_uncertainty_score":0.5210022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01986764381361206,"score_gpt":0.2864714026627686,"score_spread":0.2666037588491565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}