{"id":"W3214753493","doi":"10.1139/bcb-2021-0322","title":"SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Apoptosis; Cancer research; Vascular smooth muscle; Phosphorylation; Cell biology; Biology; Calcification; Signal transduction; LY294002; Chemistry; Endocrinology; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322867,0.0004088283,0.0003948174,0.0003243783,0.0001884539,0.0002410716,0.0004076631,0.0003371593,0.001918909],"category_scores_gemma":[0.00009606035,0.0001087481,0.0003601676,0.0001788799,0.000222811,0.0002492789,0.0002386616,0.0009158826,0.0002166388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183374,"about_ca_system_score_gemma":0.0002575399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002057381,"about_ca_topic_score_gemma":0.000537248,"domain_scores_codex":[0.9999154,0.00001318666,0.000009445754,0.00001748038,0.00002764718,0.00001683636],"domain_scores_gemma":[0.9999634,0.000004877892,0.000009424397,0.000003091071,0.000007047919,0.00001218856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009933782,0.0003401226,0.0004886094,0.0005952904,0.00007269738,0.0003169594,0.00004443389,0.0002366861,0.9752956,0.0005628641,0.0006981405,0.02035519],"study_design_scores_gemma":[0.0008848428,0.003914789,0.008527608,0.00005522293,0.0003719245,0.002024658,0.00008660868,0.002329639,0.9498417,0.0005508641,0.03137586,0.00003618895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558939,0.02742027,0.009153443,0.0008787393,0.0003859378,0.0001649269,0.0007980255,0.0005248799,0.004779856],"genre_scores_gemma":[0.980684,0.009365232,0.005278602,0.0002740959,0.00006515863,0.0001138762,0.0008775657,0.00002479382,0.00331673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918909,"threshold_uncertainty_score":0.00641942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008821733786571506,"score_gpt":0.2519260503202352,"score_spread":0.2431043165336637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}