{"id":"W3214768513","doi":"10.1182/blood-2021-154000","title":"Validation of <i>NMT1</i> and <i>NMT2</i> As Novel Drug Targets in Adult Acute Myeloid Leukemia: Rationale for N-Myristoyltransferase Inhibition with Pclx-001 for Clinical Trials","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Myristoylation; Biology; Myeloid leukemia; Cancer research; Kinase; Leukemia; Pharmacology; Phosphorylation; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002467361,0.0005922139,0.0009396918,0.000363056,0.0002281481,0.001329997,0.0006609471,0.0006110412,0.002475098],"category_scores_gemma":[0.001124277,0.0001763828,0.0007253402,0.0005374372,0.0004264391,0.0005257572,0.0003814899,0.001368788,0.001008849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001190438,"about_ca_system_score_gemma":0.001260385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003874691,"about_ca_topic_score_gemma":0.0008573601,"domain_scores_codex":[0.9995018,0.0001613239,0.00005650637,0.00008999123,0.0001199662,0.00007039955],"domain_scores_gemma":[0.9992915,0.0001115204,0.0001650144,0.00005511269,0.000215442,0.0001613252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01871559,0.002596185,0.02852224,0.002978858,0.0007527948,0.0005298005,0.0001620497,0.004173844,0.7256967,0.002913643,0.01006536,0.2028929],"study_design_scores_gemma":[0.01198693,0.07717297,0.0669836,0.001072259,0.002401195,0.003804016,0.0003893067,0.01112983,0.6407196,0.003568294,0.1806413,0.0001306013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9128855,0.04441674,0.01169773,0.005768587,0.0004597206,0.003446453,0.007940436,0.0006621407,0.0127228],"genre_scores_gemma":[0.9510319,0.01471687,0.01323856,0.002593898,0.0001816587,0.002157602,0.01220641,0.0001146126,0.003758619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002475098,"threshold_uncertainty_score":0.01304883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564804802804132,"score_gpt":0.3131186902226401,"score_spread":0.2874706421945988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}