{"id":"W3214773827","doi":"10.3389/fimmu.2021.744763","title":"Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Breakthrough T1D Canada; National Institute of Allergy and Infectious Diseases; University of California, San Francisco","keywords":"Medicine; Manufacturing process; Good manufacturing practice; Polyclonal antibodies; Clinical trial; Internal medicine; Immunology; Biology; Biotechnology; Antigen; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02711408,0.0007675436,0.0008730536,0.001073946,0.0005975665,0.002208675,0.001293632,0.001230474,0.001143892],"category_scores_gemma":[0.01733065,0.0003170545,0.0007128321,0.001508337,0.001812824,0.001272068,0.001635227,0.001495711,0.0005125915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173875,"about_ca_system_score_gemma":0.002320489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001519806,"about_ca_topic_score_gemma":0.00156413,"domain_scores_codex":[0.9887425,0.004382223,0.00131257,0.001989772,0.002713431,0.0008595558],"domain_scores_gemma":[0.9806237,0.007823358,0.00331357,0.002298679,0.003970918,0.001969832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003081073,0.002933919,0.1476182,0.001001399,0.0003179157,0.001433541,0.004099648,0.00461367,0.01892115,0.001220136,0.003510725,0.8112486],"study_design_scores_gemma":[0.001351167,0.1127527,0.5169323,0.003301823,0.001436925,0.0333058,0.009033626,0.0135419,0.1567071,0.005743349,0.1453413,0.0005521231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448307,0.02866347,0.01687606,0.001844754,0.0001446305,0.0002608457,0.0003145056,0.0001950849,0.006869974],"genre_scores_gemma":[0.9579384,0.01723169,0.01962793,0.001723841,0.0002932104,0.0001426285,0.00108036,0.0001706004,0.001791419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02711408,"threshold_uncertainty_score":0.1433946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008208090132739647,"score_gpt":0.2123628881851832,"score_spread":0.2041547980524435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}