{"id":"W3214849846","doi":"10.1093/neuonc/noab196.548","title":"NIMG-50. DEUTERIUM METABOLIC IMAGING OF THE ALTERNATIVE LENGTHENING OF TELOMERES PATHWAY REPORTS ON TUMOR BURDEN AND PSEUDOPROGRESSION IN LOW-GRADE GLIOMAS","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Ontario Brain Institute","funders":"","keywords":"Telomere; Glioma; Glycolysis; Cancer research; Neurosphere; Flux (metallurgy); In vivo; Magnetic resonance imaging; Chemistry; Biology; Medicine; Enzyme; Biochemistry; In vitro; DNA; Endothelial stem cell; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363734,0.0002057567,0.0001319181,0.0002469099,0.0001009941,0.0001875677,0.0002051387,0.0002954437,0.001556481],"category_scores_gemma":[0.00008096547,0.000126914,0.00009177965,0.000183457,0.000151233,0.0001598785,0.0001452724,0.0002437963,0.0002379754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002257542,"about_ca_system_score_gemma":0.0001557523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001888451,"about_ca_topic_score_gemma":0.003044884,"domain_scores_codex":[0.9999528,0.00001062889,0.000002290722,0.000009388917,0.00001217737,0.00001270988],"domain_scores_gemma":[0.9999689,0.000005489782,0.000007343171,0.000002898711,0.000004286499,0.00001102865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001753024,0.00001574337,0.0004047606,0.00003545631,0.000008064877,0.00006529452,0.0000127131,0.00004644373,0.9971014,0.00005651767,0.0001144439,0.001963874],"study_design_scores_gemma":[0.00003144574,0.0004539759,0.01649266,0.000009267495,0.00004899042,0.0005907443,0.00005283173,0.001945318,0.9763355,0.00008702524,0.003944928,0.000007440651],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840615,0.003731101,0.006207946,0.0001695419,0.00003022467,0.000032635,0.0007051769,0.0001678251,0.004893874],"genre_scores_gemma":[0.9843467,0.001742342,0.007180391,0.0001297287,0.000008663475,0.00005709122,0.001181541,0.00005430927,0.005299247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888451,"threshold_uncertainty_score":0.005206943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119827255835246,"score_gpt":0.2696421688163785,"score_spread":0.2576594432328539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}