{"id":"W3215006483","doi":"10.1111/jdv.17836","title":"Ixekizumab provides persistent improvements in health‐related quality of life and the sexual impact associated with moderate‐to‐severe genital psoriasis in adult patients during a 52‐week, randomised, placebo‐controlled, phase 3 clinical trial","year":2021,"lang":"en","type":"letter","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Guenther Dermatology Research Centre","funders":"Eli Lilly and Company","keywords":"Ixekizumab; Medicine; Psoriasis; Placebo; Sex organ; Quality of life (healthcare); Dosing; Internal medicine; Dermatology Life Quality Index; Secukinumab; Dermatology; Alternative medicine; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002289078,0.0009890081,0.002112602,0.0002377005,0.0003673788,0.001164204,0.0006812665,0.001288256,0.008173065],"category_scores_gemma":[0.001788253,0.000439852,0.001922376,0.0003207866,0.0006561201,0.0007963686,0.0002824568,0.002931139,0.0008923524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003676097,"about_ca_system_score_gemma":0.0005531689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003500269,"about_ca_topic_score_gemma":0.0008583005,"domain_scores_codex":[0.9994202,0.0002797921,0.00005526347,0.00007320369,0.00006617364,0.0001054459],"domain_scores_gemma":[0.9990993,0.0002826288,0.0002194266,0.00006124377,0.00007384846,0.0002636418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.949396,0.00892828,0.001491636,0.001211892,0.001480805,0.00008241983,0.00008121969,0.0002514522,0.004697415,0.00008637211,0.002493867,0.0297987],"study_design_scores_gemma":[0.8866833,0.1019601,0.007799836,0.00008390737,0.000609964,0.00009634304,0.00003263135,0.0003571912,0.0006983481,0.00009665363,0.001563615,0.00001808472],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743432,0.01315405,0.000516974,0.001522515,0.0009899035,0.003412892,0.002246457,0.0001546972,0.003659247],"genre_scores_gemma":[0.9864389,0.00423579,0.0007560904,0.001545517,0.0008585289,0.001941794,0.001120672,0.00002252237,0.0030802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008173065,"threshold_uncertainty_score":0.02734166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03883039974010785,"score_gpt":0.3024456140539665,"score_spread":0.2636152143138587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}