{"id":"W3215055113","doi":"10.1101/2021.11.25.470051","title":"Genetic perturbation enhances functional heterogeneity in alkaline phosphatase","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science","keywords":"Genetic heterogeneity; Alkaline phosphatase; Enzyme; Mutant; Biology; Phosphatase; Point mutation; Genetics; Spatial heterogeneity; Functional analysis; Chemistry; Biochemistry; Gene; Phenotype; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007045784,0.0006749859,0.001011071,0.000401594,0.000161666,0.0001605635,0.0002866204,0.0004741928,0.0002763932],"category_scores_gemma":[0.001027359,0.0006917098,0.0002678564,0.0007888096,0.0002218792,0.000182742,0.0008038327,0.001177626,0.00009096305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006954806,"about_ca_system_score_gemma":0.001529972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002128434,"about_ca_topic_score_gemma":0.00003982112,"domain_scores_codex":[0.9957265,0.0002063976,0.0008400668,0.001430909,0.001020659,0.0007754422],"domain_scores_gemma":[0.996745,0.0001434344,0.0003306434,0.001365833,0.0009913585,0.0004237175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007268204,0.002069165,0.1121614,0.003721353,0.001575051,0.002941953,0.00004707801,0.0005472684,0.8727346,0.000329887,0.003117733,0.00002768276],"study_design_scores_gemma":[0.001561747,0.0001143646,0.5379745,0.001023997,0.0002318247,1.905444e-7,0.00001122206,0.001437173,0.4544545,0.000003152163,0.002487822,0.0006995201],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462355,0.04890459,0.001461337,0.000638921,0.0008889799,0.001147032,0.0005062489,0.000211928,0.000005475573],"genre_scores_gemma":[0.9860203,0.005912766,0.006081681,0.0004565702,0.0008459327,0.0005329476,0.0000188003,0.000117177,0.00001386787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.425813,"threshold_uncertainty_score":0.9995534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588224344671305,"score_gpt":0.2719898256444264,"score_spread":0.2461075821977133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}