{"id":"W3215114010","doi":"10.1093/neuonc/noab196.231","title":"CTNI-06. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; McGill University; Hospital for Sick Children; Centre Hospitalier Universitaire de Sherbrooke; Izaak Walton Killam Health Centre; Centre hospitalier universitaire de Québec; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Trametinib; Tolerability; Internal medicine; MAPK/ERK pathway; Progressive disease; Oncology; Progression-free survival; Adverse effect; Gastroenterology; Surgery; Disease; Overall survival; Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001461736,0.001597873,0.001638725,0.0004281676,0.000393084,0.001029284,0.001169174,0.001102689,0.002841035],"category_scores_gemma":[0.000703068,0.0005220979,0.0009781902,0.0005193235,0.0007486916,0.0007601467,0.0003358713,0.00335469,0.0008194615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001407637,"about_ca_system_score_gemma":0.002396228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002127087,"about_ca_topic_score_gemma":0.006703699,"domain_scores_codex":[0.9996827,0.0001491386,0.00001484615,0.00004496469,0.00003246589,0.00007595963],"domain_scores_gemma":[0.9994641,0.00005299079,0.00008863013,0.00002898211,0.00003411568,0.0003311858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5055586,0.1056741,0.01906407,0.002234091,0.002012606,0.001592637,0.0008352036,0.006923303,0.08892825,0.001030413,0.01416233,0.2519843],"study_design_scores_gemma":[0.5206526,0.4379364,0.02189564,0.0000889556,0.0006120268,0.001624209,0.0001159747,0.002889724,0.007445005,0.0001804729,0.006495312,0.00006378024],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901405,0.003245364,0.0004480036,0.0006417746,0.000104582,0.001974833,0.001432177,0.000134104,0.001878575],"genre_scores_gemma":[0.9831694,0.003972117,0.002530273,0.0008732451,0.0001682878,0.002630869,0.003520195,0.00004290952,0.003092609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002841035,"threshold_uncertainty_score":0.0102132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196916038678489,"score_gpt":0.2928475265020674,"score_spread":0.2731559226342185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}