{"id":"W3215126132","doi":"10.1016/j.cjco.2021.11.009","title":"Treatment of Homozygous Familial Hypercholesterolemia With Evinacumab","year":2021,"lang":"en","type":"article","venue":"CJC Open","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Pfizer; HLS Therapeutics; Heart and Stroke Foundation of Canada; Sanofi; Canadian Institutes of Health Research; Novartis","keywords":"Medicine; Ezetimibe; Familial hypercholesterolemia; LDL apheresis; Internal medicine; Gastroenterology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003337596,0.0001098049,0.0004401949,0.00002655317,0.00003103338,0.00002391216,0.0001021114,0.00004226181,0.0001974036],"category_scores_gemma":[0.00002181556,0.00007303795,0.00005410073,0.0001330457,0.00005175121,0.00008798804,0.00006336862,0.00003762073,0.00004001449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000327956,"about_ca_system_score_gemma":0.0003364056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551578,"about_ca_topic_score_gemma":0.00006381376,"domain_scores_codex":[0.9993305,0.00002821811,0.0001434621,0.0002127241,0.0001401809,0.0001448964],"domain_scores_gemma":[0.9993339,0.00001832256,0.0000374734,0.0004193528,0.00009276093,0.00009818129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008056292,0.008980628,0.2059184,0.0005565498,0.00144136,0.004438675,0.0101114,0.00003069791,0.06171606,0.003400735,0.009054326,0.6862949],"study_design_scores_gemma":[0.05097375,0.005000127,0.2339532,0.000322257,0.001375562,0.001911298,0.005405395,0.00003396612,0.07391725,0.000205092,0.6263401,0.0005619838],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513322,0.001095811,0.00002380258,0.0006383472,0.0001168862,0.0004379009,0.00001614755,0.00001495166,0.04632394],"genre_scores_gemma":[0.9902065,0.0003578869,0.001643584,0.0003758669,0.0001193308,0.00004018602,0.00005384566,0.00001922874,0.00718357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.685733,"threshold_uncertainty_score":0.2978401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427812554069425,"score_gpt":0.3019679609277349,"score_spread":0.2776898353870406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}