{"id":"W3215127069","doi":"10.1016/j.jaip.2021.11.017","title":"Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results","year":2021,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Ottawa Allergy Research Corporation; University of Ottawa; Research Canada; BC Children's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Pfizer Pharmaceuticals; Sanofi Genzyme; Genentech; National Peanut Board; HAL Allergy; National Institutes of Health; National Health and Medical Research Council; AstraZeneca; Allergy Therapeutics; Novartis; BioCryst; Immune Tolerance Network; Astellas Pharma Canada; Aimmune Therapeutics; CSL Behring; Roche; Sanofi; Merck; GlaxoSmithKline; Bausch Health; U.S. Food and Drug Administration; Center of Excellence for the Oceans, National Taiwan Ocean University; Wallace Research Foundation; Duke Clinical Research Institute; Food Allergy Research and Education; LEO Pharma Research Foundation; Pfizer","keywords":"Peanut allergy; Medicine; Placebo; Anaphylaxis; Allergy; Randomized controlled trial; Adverse effect; Pediatrics; Clinical trial; Internal medicine; Food allergy; Immunology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.02437182,0.0002116777,0.001828829,0.000196109,0.00008034503,0.00001445699,0.0003834811,0.0005383105,0.0001204078],"category_scores_gemma":[0.03428869,0.0001345275,0.0005922475,0.0004198982,0.001351918,0.0001983217,0.0001650241,0.003236096,0.00000564381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003849957,"about_ca_system_score_gemma":0.0007239108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752564,"about_ca_topic_score_gemma":0.0002846912,"domain_scores_codex":[0.9830063,0.01136226,0.004560555,0.0002958347,0.0004259019,0.0003491172],"domain_scores_gemma":[0.9693611,0.02789375,0.001438999,0.0005870268,0.000594499,0.0001246177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.966911,0.003294044,0.0002110224,0.000004346996,0.008282965,0.001205236,0.0003758117,0.00003363178,0.0001581638,0.0006761583,0.0002159106,0.01863177],"study_design_scores_gemma":[0.9382789,0.009587639,0.03240481,0.0003910251,0.0003180616,0.004481282,0.001559919,0.00008288919,0.00009605844,0.0007547312,0.01184698,0.0001976972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949155,0.02068572,0.00002548603,0.0242848,0.0008179221,0.0005056232,0.000004512638,0.000006759933,0.004514188],"genre_scores_gemma":[0.5807225,0.417192,0.000466955,0.0008856562,0.0003753355,0.000002735287,0.00001008807,0.00001686388,0.0003278766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3965063,"threshold_uncertainty_score":0.9990635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0393297377092952,"score_gpt":0.4042165290587194,"score_spread":0.3648867913494241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}