{"id":"W3215127069","doi":"10.1016/j.jaip.2021.11.017","title":"Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results","year":2021,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Ottawa Allergy Research Corporation; University of Ottawa; Research Canada; BC Children's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Pfizer Pharmaceuticals; Sanofi Genzyme; Genentech; National Peanut Board; HAL Allergy; National Institutes of Health; National Health and Medical Research Council; AstraZeneca; Allergy Therapeutics; Novartis; BioCryst; Immune Tolerance Network; Astellas Pharma Canada; Aimmune Therapeutics; CSL Behring; Roche; Sanofi; Merck; GlaxoSmithKline; Bausch Health; U.S. Food and Drug Administration; Center of Excellence for the Oceans, National Taiwan Ocean University; Wallace Research Foundation; Duke Clinical Research Institute; Food Allergy Research and Education; LEO Pharma Research Foundation; Pfizer","keywords":"Peanut allergy; Medicine; Placebo; Anaphylaxis; Allergy; Randomized controlled trial; Adverse effect; Pediatrics; Clinical trial; Internal medicine; Food allergy; Immunology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00735054,0.001394643,0.002838419,0.0005137241,0.0003910208,0.001339772,0.0009591921,0.002639111,0.008530882],"category_scores_gemma":[0.008042221,0.0005691406,0.002812403,0.0004836787,0.001598388,0.001301372,0.0005723253,0.002419241,0.0007899232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006623237,"about_ca_system_score_gemma":0.001004719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003059743,"about_ca_topic_score_gemma":0.0006408848,"domain_scores_codex":[0.9954457,0.0032836,0.0003106689,0.0004123055,0.0003110715,0.0002366408],"domain_scores_gemma":[0.9940374,0.002760123,0.00178634,0.0004042966,0.0003773076,0.0006344924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9837436,0.001735092,0.0007078617,0.00144353,0.00150663,0.00003960331,0.00004087718,0.0002322937,0.001031212,0.000127275,0.0005412809,0.008850813],"study_design_scores_gemma":[0.955704,0.03943975,0.001993279,0.0001016286,0.0009409201,0.00005611723,0.00001600975,0.0002628879,0.0003143777,0.0001795349,0.0009766008,0.00001494059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9248924,0.04445434,0.003742987,0.003142487,0.0009213202,0.01253063,0.004540835,0.0003380803,0.005436842],"genre_scores_gemma":[0.9617736,0.009796649,0.005527988,0.001710996,0.001088405,0.01437216,0.002462471,0.00005402093,0.003213736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008530882,"threshold_uncertainty_score":0.03887379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0393297377092952,"score_gpt":0.4042165290587194,"score_spread":0.3648867913494241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}