{"id":"W3215129775","doi":"10.1136/bmjopen-2021-054885","title":"FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Astellas Pharma; Shionogi; Eisai; H. Lundbeck A/S; FUJIFILM Toyama Chemical; Canon Medical Systems Corporation; EA Pharma Co., Ltd.; Nihon Medi-Physics; Eisai Canada; Pfizer; Meiji Seika Pharma; Eli Lilly and Company","keywords":"Medicine; Primary Insomnia; Glymphatic system; Insomnia; Sleep disorder; Sleep (system call); Pittsburgh Sleep Quality Index; Physical therapy; Internal medicine; Psychiatry; Sleep quality","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01351953,0.004354395,0.007458585,0.001029964,0.003157812,0.001282671,0.002848705,0.003978326,0.03063202],"category_scores_gemma":[0.006908051,0.00182938,0.002241152,0.001325707,0.002284797,0.001881018,0.001469476,0.003527471,0.007572746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002271985,"about_ca_system_score_gemma":0.01116161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723762,"about_ca_topic_score_gemma":0.003438977,"domain_scores_codex":[0.9937049,0.003266475,0.0007364542,0.0007953175,0.0007709959,0.0007258076],"domain_scores_gemma":[0.9946679,0.0006174068,0.001194616,0.0007566593,0.001158215,0.001605251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8568864,0.07349331,0.002807795,0.007621966,0.0008915549,0.000264072,0.0004695248,0.001204331,0.00775904,0.001256024,0.01257378,0.03477214],"study_design_scores_gemma":[0.7191543,0.2390113,0.01236226,0.0008752418,0.0005629489,0.00009013214,0.0002177973,0.001094676,0.001484271,0.0008025377,0.02422644,0.0001181126],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02023044,0.0004538323,0.002533188,0.0002055542,0.0002612505,0.972982,0.001949301,0.0001286502,0.00125577],"genre_scores_gemma":[0.0122334,0.0001842121,0.003104614,0.0002994581,0.00008028476,0.983059,0.000403808,0.000007762628,0.0006273437],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03063202,"threshold_uncertainty_score":0.1024743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1114209534300025,"score_gpt":0.3994982597353333,"score_spread":0.2880773063053308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}