{"id":"W3215133919","doi":"10.3390/ijms222313006","title":"MT1-MMP Cooperates with TGF-β Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université du Québec à Montréal","keywords":"Cancer research; Signal transduction; Epithelial–mesenchymal transition; Snail; Cell biology; Biology; Gene silencing; Chemistry; Metastasis; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006724693,0.0002285442,0.0002865807,0.000212955,0.0001828866,0.0002820225,0.0000726174,0.0001285751,0.0005669951],"category_scores_gemma":[0.00005847338,0.0001177692,0.0002483771,0.0002750606,0.0001075467,0.00009246996,0.0001407456,0.0003246091,0.0002845909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461676,"about_ca_system_score_gemma":0.0002303918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002910736,"about_ca_topic_score_gemma":0.004456862,"domain_scores_codex":[0.9998913,0.000009821157,0.00001020797,0.00001648742,0.00003549988,0.00003663186],"domain_scores_gemma":[0.9999675,0.000003288094,0.00001028165,0.000003424305,0.000006788606,0.000008802855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008662044,0.00002128998,0.0007587799,0.00003607039,0.000005886416,0.0000609844,0.00002806086,0.00007298153,0.9975184,0.00006048552,0.0001048527,0.001245583],"study_design_scores_gemma":[0.00001210729,0.0001286653,0.02193773,0.000006455501,0.00002031969,0.0001902332,0.00008707267,0.00227817,0.9725173,0.00004596085,0.002770728,0.00000539188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944838,0.001028731,0.00159999,0.00007465135,0.00001977309,0.00002946379,0.001242277,0.0001038697,0.001417412],"genre_scores_gemma":[0.9936675,0.0007264749,0.001628984,0.00006916279,0.000005116339,0.0000451293,0.001636677,0.00001519821,0.002205699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910736,"threshold_uncertainty_score":0.005787611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006918811700660944,"score_gpt":0.2486975855374703,"score_spread":0.2417787738368094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}