{"id":"W3215135819","doi":"10.1002/anie.202114858","title":"The Chiral Target of Daptomycin Is the 2<i>R</i>,2′<i>S</i> Stereoisomer of Phosphatidylglycerol","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphatidylglycerol; Daptomycin; Stereochemistry; Enantiopure drug; Liposome; Chemistry; Enantiomer; Hydroformylation; Membrane; Phospholipid; Biochemistry; Phosphatidylcholine; Biology; Bacteria; Enantioselective synthesis; Rhodium; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008661033,0.0002707049,0.0001928357,0.0001313122,0.0001325959,0.0003204693,0.0001353288,0.0001933422,0.0009315188],"category_scores_gemma":[0.00009387794,0.00008363318,0.0001165822,0.0001182194,0.0002030477,0.0001362695,0.0001649254,0.0004104739,0.0005477797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625555,"about_ca_system_score_gemma":0.0002054785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003402311,"about_ca_topic_score_gemma":0.0002890594,"domain_scores_codex":[0.9999132,0.00001362208,0.000005194695,0.00002298346,0.0000250755,0.00001993516],"domain_scores_gemma":[0.9999381,0.000009271363,0.00001836143,0.000005871023,0.000009493011,0.00001878441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003652161,0.000006562586,0.0001168622,0.00001358441,9.763469e-7,0.00003774351,0.000004095114,0.00002831207,0.9976398,0.0001802434,0.00002836404,0.001906996],"study_design_scores_gemma":[0.000002820452,0.00006403631,0.0005558195,0.00000152576,0.000001565417,0.0001248068,0.00000789664,0.000121228,0.9974008,0.00003728951,0.001680272,0.000001934031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975318,0.002224591,0.009491466,0.0002312123,0.00008650434,0.00005075681,0.0003569249,0.0001414566,0.01209913],"genre_scores_gemma":[0.9897047,0.001024854,0.005748088,0.0001190915,0.0000128236,0.00001563546,0.0003015955,0.0000261257,0.003047173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009315188,"threshold_uncertainty_score":0.00311631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009394405285928593,"score_gpt":0.2298797885998617,"score_spread":0.2204853833139331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}