{"id":"W3215163439","doi":"10.1093/neuonc/noab196.001","title":"EPCO-02. GERMLINE SINGLE NUCLEOTIDE POLYMORPHISM rs55705857 AT 8q24 INTERACTS WITH SOMATIC IDH1 MUTATION TO ENHANCE HUMAN GLIOMA FORMATION","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; Single-nucleotide polymorphism; Glioma; Biology; IDH1; Germline; Locus (genetics); Genetics; Molecular biology; Germline mutation; Cancer research; Genotype; Mutant; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479252,0.0002564022,0.0002324591,0.0004198532,0.0001933531,0.0002480418,0.000241835,0.000289583,0.008758063],"category_scores_gemma":[0.0003754472,0.0001109552,0.0002834001,0.0003775359,0.000174934,0.00006721507,0.0002187713,0.0003293969,0.0009014119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001680062,"about_ca_system_score_gemma":0.0001646998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633219,"about_ca_topic_score_gemma":0.001828887,"domain_scores_codex":[0.999864,0.00002021406,0.000008682423,0.00006101398,0.000023218,0.00002283512],"domain_scores_gemma":[0.999734,0.00006980731,0.00007666423,0.00002806076,0.00001608323,0.00007542869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004565059,0.0004763197,0.2051979,0.000264984,0.0004223537,0.003121438,0.0001548005,0.000636403,0.7545959,0.0008065361,0.004033717,0.02572457],"study_design_scores_gemma":[0.0003447821,0.0007009695,0.936825,0.00004677663,0.000399419,0.004424019,0.0001322745,0.00278818,0.04676339,0.0004975641,0.007055682,0.00002186791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995935,0.0002445329,0.0006224439,0.00009099388,0.00002786451,0.00001759808,0.001671297,0.00004584239,0.001344495],"genre_scores_gemma":[0.9965443,0.00007333815,0.0004396799,0.0001146549,0.00001245214,0.00002045925,0.001184391,0.00003011945,0.001580635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008758063,"threshold_uncertainty_score":0.02929866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959444430569937,"score_gpt":0.3120779441274625,"score_spread":0.2924834998217631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}