{"id":"W3215169928","doi":"10.1093/braincomms/fcab271","title":"Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration","year":2021,"lang":"en","type":"article","venue":"Brain Communications","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia; Praxis Spinal Cord Institute; University of Manitoba","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; U.S. Department of Veterans Affairs; Hunter College; National Institutes of Health; Icahn School of Medicine at Mount Sinai","keywords":"Regeneration (biology); Extracellular; Histone; Cell biology; Myelin; Neurite; Inhibitory postsynaptic potential; Biology; Chemistry; Neuroscience; In vitro; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086331,0.0004515964,0.0001275689,0.0002479616,0.0001412775,0.000332952,0.0001832399,0.000177942,0.001166376],"category_scores_gemma":[0.00011193,0.00007548372,0.0001930195,0.0001148077,0.0002147032,0.0001939332,0.0002112253,0.0002816042,0.0002282976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002328457,"about_ca_system_score_gemma":0.0001705474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004698495,"about_ca_topic_score_gemma":0.0007770594,"domain_scores_codex":[0.9999354,0.000007953212,0.000004847382,0.00001241293,0.00002437897,0.00001488098],"domain_scores_gemma":[0.9998999,0.00001384406,0.00003159762,0.000007662647,0.00001771661,0.00002923311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205289,0.00001405196,0.0005513028,0.00009832033,0.00001340368,0.000109953,0.0000105249,0.00006610648,0.9917733,0.0004452922,0.00007421232,0.006723045],"study_design_scores_gemma":[0.00002985715,0.000483683,0.01378347,0.00003745682,0.00005350818,0.0006541542,0.00003555206,0.0005935773,0.9713136,0.0002805934,0.01272487,0.000009750829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449632,0.02620249,0.01604292,0.0001836021,0.0001395932,0.00008459614,0.0007731419,0.0002133513,0.01139724],"genre_scores_gemma":[0.9811369,0.005879701,0.005241822,0.0001246722,0.00007808746,0.00004670697,0.0008312901,0.0000273928,0.006633476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166376,"threshold_uncertainty_score":0.003901899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06868126462843768,"score_gpt":0.3003062524269096,"score_spread":0.2316249877984719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}