{"id":"W3215197047","doi":"10.1093/neuonc/noab274","title":"Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institute for Health and Care Research","keywords":"Trk receptor; Central nervous system; Medicine; Fusion; Primary (astronomy); Neuroscience; Cancer research; Internal medicine; Biology; Neurotrophin; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048341,0.0001457101,0.0006170971,0.0001007193,0.00004194124,0.000005075066,0.00004005681,0.000118819,0.00003590903],"category_scores_gemma":[0.0001460755,0.0001253309,0.00007452884,0.000240132,0.00006638396,0.00002514989,0.00008531632,0.0001962222,0.000005890799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184279,"about_ca_system_score_gemma":0.0003169195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007548876,"about_ca_topic_score_gemma":0.00005474723,"domain_scores_codex":[0.9985995,0.0002596744,0.0003773797,0.0003384899,0.0001414368,0.0002835557],"domain_scores_gemma":[0.9987814,0.0006802942,0.00011775,0.0001954702,0.00007431873,0.0001507574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003383899,0.004779861,0.2148287,0.0005282366,0.0002238683,0.02834895,0.00212495,0.0000700666,0.6021234,0.001050403,0.0007212164,0.1418165],"study_design_scores_gemma":[0.0100643,0.001574644,0.917527,0.0003063313,0.0001680494,0.001799568,0.0004685628,0.00004686645,0.06434432,0.000005408066,0.00359344,0.0001015683],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908,0.0005504932,0.000003037515,0.001710901,0.0002886102,0.000578648,0.00002085907,0.00002957383,0.006017928],"genre_scores_gemma":[0.9988834,0.0001787698,0.0001709142,0.0005853064,0.00007623921,0.00003503346,0.0000410884,0.00001784044,0.00001142739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7026982,"threshold_uncertainty_score":0.5110846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173105781653636,"score_gpt":0.2667124807461399,"score_spread":0.2549814229296035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}