{"id":"W3215197047","doi":"10.1093/neuonc/noab274","title":"Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institute for Health and Care Research","keywords":"Trk receptor; Central nervous system; Medicine; Fusion; Primary (astronomy); Neuroscience; Cancer research; Internal medicine; Biology; Neurotrophin; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001204595,0.0002252185,0.0009327733,0.0002148122,0.0001456056,0.0004020578,0.0001972443,0.0002195875,0.001144514],"category_scores_gemma":[0.0009104529,0.00007611416,0.0005054359,0.0002344383,0.0002483061,0.0002577023,0.0001567,0.0006719022,0.0002700414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001065449,"about_ca_system_score_gemma":0.0005960597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008506642,"about_ca_topic_score_gemma":0.001972554,"domain_scores_codex":[0.9995957,0.0001421784,0.00003997674,0.00005823886,0.0001020383,0.0000619787],"domain_scores_gemma":[0.9993477,0.0001652234,0.0002132076,0.00002494678,0.0001073827,0.0001414824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1231312,0.007595934,0.2192731,0.002807195,0.002434195,0.001569679,0.000320422,0.006343164,0.1250212,0.000253235,0.01038369,0.5008669],"study_design_scores_gemma":[0.03346926,0.2835484,0.5971291,0.0003482227,0.00283284,0.008297327,0.0002404716,0.006880953,0.05579763,0.0002971045,0.01109324,0.00006546362],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990413,0.006958543,0.0002160193,0.0001569525,0.00002023831,0.0001321183,0.0004739161,0.00003051819,0.001598791],"genre_scores_gemma":[0.9970227,0.001612719,0.0001688965,0.0001301604,0.00003215776,0.00007016856,0.0007005473,0.000005361333,0.0002573206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204595,"threshold_uncertainty_score":0.007730424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173105781653636,"score_gpt":0.2667124807461399,"score_spread":0.2549814229296035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}