{"id":"W3215242814","doi":"10.3390/ijms222312663","title":"Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; University of Pittsburgh","keywords":"Hindbrain; Homeobox; Midbrain; TPH2; Cell fate determination; Biology; Forebrain; Neuroscience; Floor plate; Cell biology; Serotonergic; Embryo; Transcription factor; Gene; Genetics; Receptor; Central nervous system; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006806552,0.000386961,0.0002989797,0.0001713098,0.0002106355,0.0004665873,0.000244562,0.0002621014,0.001629224],"category_scores_gemma":[0.00009088937,0.0002419208,0.0002150251,0.00006938229,0.0002020493,0.0001695431,0.0006325213,0.0006074865,0.0007796205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985411,"about_ca_system_score_gemma":0.00027302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331295,"about_ca_topic_score_gemma":0.002405809,"domain_scores_codex":[0.9998498,0.00001324384,0.00001717848,0.00003951924,0.00003926427,0.00004102631],"domain_scores_gemma":[0.9998603,0.000006890276,0.0000417701,0.00001138474,0.0000158804,0.00006381084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004781098,0.000006820081,0.0006205723,0.00001421237,0.000002768109,0.0001007504,0.00001183244,0.00002724855,0.9984603,0.00007605597,0.0000234047,0.0006081887],"study_design_scores_gemma":[0.00002819677,0.0001009012,0.1253198,0.0000212728,0.00003359222,0.001150721,0.0001518221,0.002153405,0.8626724,0.00009995851,0.008255737,0.00001205912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923535,0.001283846,0.002754184,0.00008728971,0.00003229106,0.00001805573,0.0006697382,0.00008924424,0.0027118],"genre_scores_gemma":[0.9885444,0.0005499455,0.0009978184,0.00005026572,0.000008532497,0.00002338488,0.0006734109,0.00005762109,0.009094554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629224,"threshold_uncertainty_score":0.005450308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007055766027589281,"score_gpt":0.2471915102877918,"score_spread":0.2401357442602025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}