{"id":"W3215248537","doi":"10.1093/neuonc/noab196.879","title":"TMOD-18. DIRECT IN VIVO CRISPR SCREEN IDENTIFIES COOPERATING TUMOR SUPPRESSORS THAT DRIVE PROGRESSION OF IDH1-MUTANT LOW-GRADE GLIOMA TO AGGRESSIVE GLIOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; McGill University; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"ATRX; IDH1; Cancer research; Glioma; Mutant; Biology; PTEN; CRISPR; Mutation; PI3K/AKT/mTOR pathway; Gene; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767949,0.0003742766,0.0004252682,0.000392419,0.0001485116,0.0003207732,0.0003031008,0.0002987145,0.001816833],"category_scores_gemma":[0.00009336158,0.0001728352,0.0002747825,0.0002260185,0.0001979194,0.00006445893,0.0002198148,0.0004357357,0.0006818706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308289,"about_ca_system_score_gemma":0.0002384765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009011385,"about_ca_topic_score_gemma":0.002151556,"domain_scores_codex":[0.9998021,0.00001730874,0.00002237112,0.00005437513,0.00006660491,0.00003726806],"domain_scores_gemma":[0.9998702,0.00001938189,0.00004645488,0.00001467118,0.00001167895,0.00003757341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003701423,0.00001903186,0.0001978909,0.00002391092,0.000004354989,0.0000787227,0.000008281896,0.00006969205,0.9984204,0.00007384481,0.00007011618,0.0009968181],"study_design_scores_gemma":[0.00001815437,0.0002208578,0.003048751,0.000004864044,0.00002606498,0.0005843542,0.00001630804,0.001626476,0.9896818,0.00002977421,0.004737241,0.000005361052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654659,0.000723875,0.02179923,0.0001464359,0.00006569052,0.0003172125,0.006162541,0.001332917,0.003986183],"genre_scores_gemma":[0.971273,0.00047678,0.01509739,0.00007845814,0.000007143173,0.0001614715,0.00433761,0.0002055475,0.008362513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816833,"threshold_uncertainty_score":0.006077945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215745595864472,"score_gpt":0.3262766865455839,"score_spread":0.3047021269591367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}