{"id":"W3215270358","doi":"10.1073/pnas.2111946118","title":"BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Division of Chemistry; National Cancer Institute; Università degli Studi di Ferrara; National Institute of Environmental Health Sciences; Fondazione Umberto Veronesi; Center for Theoretical Biological Physics; Genentech; National Science Foundation; Associazione Italiana per la Ricerca sul Cancro; Welch Foundation; University of Hawaiʻi Foundation; Andrew and Jaime Sullivan Family Foundation; Ministero della Salute; U.S. Department of Defense","keywords":"Acetylation; BAP1; Cancer research; Mesothelioma; HMGB1; HDAC1; Chemistry; Carcinogenesis; Histone; Biology; Cell biology; Histone deacetylase; Gene; Biochemistry; Immunology; Medicine; Inflammation; Melanoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542704,0.0002437536,0.0001835429,0.0002200681,0.0001925195,0.0002719344,0.000266985,0.0002731151,0.002361364],"category_scores_gemma":[0.0001870306,0.0001641196,0.0002216227,0.00009338748,0.0002787678,0.0001798492,0.0003660284,0.0003063263,0.0005644581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002643767,"about_ca_system_score_gemma":0.0001072691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007485267,"about_ca_topic_score_gemma":0.0009218697,"domain_scores_codex":[0.9998204,0.00003178645,0.00001004781,0.00005439859,0.00004136588,0.00004208675],"domain_scores_gemma":[0.9998304,0.00001784985,0.00006214893,0.00002021307,0.00001917549,0.00005030738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239357,0.00001260464,0.002449413,0.00002210547,0.00001345925,0.00005693033,0.0000142834,0.00003120411,0.9964314,0.00005319005,0.00004401366,0.0007474945],"study_design_scores_gemma":[0.00003838561,0.000281602,0.1444774,0.00001031208,0.00003881154,0.0007537624,0.000170615,0.001440527,0.8497489,0.0002642096,0.002761871,0.00001357619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945674,0.001473594,0.002532632,0.000267477,0.00003497258,0.00001923858,0.0002552338,0.0000636,0.0007857967],"genre_scores_gemma":[0.9975805,0.0002852442,0.0007541483,0.00004583335,0.00001077007,0.00001195499,0.0001747052,0.00001136765,0.001125317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361364,"threshold_uncertainty_score":0.007899523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122370813424835,"score_gpt":0.274408243741309,"score_spread":0.2431845356070607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}