{"id":"W3215270358","doi":"10.1073/pnas.2111946118","title":"BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Division of Chemistry; National Cancer Institute; Università degli Studi di Ferrara; National Institute of Environmental Health Sciences; Fondazione Umberto Veronesi; Center for Theoretical Biological Physics; Genentech; National Science Foundation; Associazione Italiana per la Ricerca sul Cancro; Welch Foundation; University of Hawaiʻi Foundation; Andrew and Jaime Sullivan Family Foundation; Ministero della Salute; U.S. Department of Defense","keywords":"Acetylation; BAP1; Cancer research; Mesothelioma; HMGB1; HDAC1; Chemistry; Carcinogenesis; Histone; Biology; Cell biology; Histone deacetylase; Gene; Biochemistry; Immunology; Medicine; Inflammation; Melanoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393948,0.00007747902,0.0001132134,0.00005322495,0.00009614742,0.00001113423,0.00007953491,0.00002973327,0.00004129736],"category_scores_gemma":[0.0000263495,0.00004006504,0.00003039223,0.0001550852,0.0004594076,0.00032085,0.00005421526,0.00007405612,0.000001032323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003528975,"about_ca_system_score_gemma":0.00002412325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003125721,"about_ca_topic_score_gemma":5.167114e-8,"domain_scores_codex":[0.9987949,0.0000020465,0.0001228474,0.0001922887,0.0008060428,0.00008188126],"domain_scores_gemma":[0.9997228,0.00003162503,0.000152029,0.000007121112,0.00004156432,0.00004487356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003145814,0.0002471761,0.7563927,0.000105825,0.00008187902,1.303809e-7,0.0001205652,0.0002882059,0.239355,0.002046497,0.00008458351,0.0009628512],"study_design_scores_gemma":[0.0003380273,0.0001563124,0.6995977,0.0001089894,0.00005158315,0.00007920383,0.0002332687,0.0002945405,0.2975812,0.001364556,0.0001448965,0.00004978752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958299,0.0002093846,0.000002052152,0.001977916,0.000003274022,0.0001343584,0.000009690518,0.000004408978,0.001828947],"genre_scores_gemma":[0.9972897,0.00008394179,0.002034834,0.000266215,0.00002399477,0.00001045709,0.000001291068,0.000003864201,0.0002857568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05822612,"threshold_uncertainty_score":0.1692706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122370813424835,"score_gpt":0.274408243741309,"score_spread":0.2431845356070607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}