{"id":"W3215310816","doi":"10.5281/zenodo.5658141","title":"Dynamics of Brain Structure and its Genetic Architecture over the Lifespan","year":2020,"lang":"en","type":"preprint","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Heinz Nixdorf Stiftung; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Bergens Forskningsstiftelse; Radboud Universitair Medisch Centrum; Norges Forskningsråd; Universitair Medisch Centrum Groningen; Leids Universitair Medisch Centrum; Fondation de France; IXICO; Knut och Alice Wallenbergs Stiftelse; Horizon 2020 Framework Programme; Vetenskapsrådet; University of Southern California; Eisai; Conselho Nacional de Desenvolvimento Científico e Tecnológico; EU Joint Programme – Neurodegenerative Disease Research; Rivierduinen; GGZ inGeest; Accare; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National University of Ireland; Stockholms Läns Landsting; Fondation pour la Recherche Médicale; Bundesministerium für Bildung und Forschung; Vrije Universiteit Amsterdam; Eli Lilly and Company; Fundación Mutua Madrileña; Radboud Universiteit; Karolinska Institutet; ZonMw; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; Biogen; Agence Nationale de la Recherche; GGZ Friesland; King's College London; National Institute for Health and Care Research; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Fundación Alicia Koplowitz; BioClinica; GGZ Drenthe; Genentech; European Commission; U.S. Department of Defense; Universitetet i Bergen; Alzheimer's Disease Neuroimaging Initiative; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Medical Research Council; University of Galway; National Science Foundation; Science Foundation Ireland; Rijksuniversiteit Groningen; Bristol-Myers Squibb; Fédération pour la Recherche sur le Cerveau; Alzheimer's Association","keywords":"Brain size; Biology; Brain morphometry; Genetic architecture; Imaging genetics; Brain Structure and Function; Genome-wide association study; Atrophy; Neuroimaging; Human brain; Gene; Schizophrenia (object-oriented programming); Genetics; Neuroscience; Magnetic resonance imaging; Psychology; Genotype; Medicine; Quantitative trait locus; Single-nucleotide polymorphism; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004023864,0.0001508131,0.0001959559,0.0008581844,0.000139998,0.0005647102,0.0001779076,0.0002838674,0.002539261],"category_scores_gemma":[0.00251616,0.0001593483,0.000175758,0.0006692577,0.0003497042,0.0003281275,0.0004354342,0.0003313699,0.0004341731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023706,"about_ca_system_score_gemma":0.0001748713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002673659,"about_ca_topic_score_gemma":0.002599547,"domain_scores_codex":[0.9998462,0.00003259388,0.000005139936,0.0000656831,0.00002642505,0.00002384251],"domain_scores_gemma":[0.9991558,0.0002485963,0.0002685366,0.0001233809,0.0001045155,0.0000992044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007856245,0.00009112235,0.828894,0.0001199685,0.0007862319,0.001545807,0.00160157,0.00549198,0.04463465,0.005999058,0.005319521,0.1047305],"study_design_scores_gemma":[0.00000227887,0.00003819144,0.9950078,0.000008540521,0.000023082,0.0004637513,0.00009663664,0.0007301919,0.0003834894,0.002497401,0.000741875,0.000006732741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927455,0.000831236,0.002011446,0.0004164673,0.00001510333,0.000003704984,0.00206402,0.00005268128,0.001859927],"genre_scores_gemma":[0.9968568,0.0004782243,0.0006924672,0.00002391379,0.00001427061,0.000007714017,0.0008887191,0.00002485806,0.001012909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002673659,"threshold_uncertainty_score":0.008494616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712476560134149,"score_gpt":0.2456087268620764,"score_spread":0.2284839612607349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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