{"id":"W3215368970","doi":"10.1161/res.129.suppl_1.p425","title":"Abstract P425: Sirtuin 3 Attenuates Doxorubicin Induced Cardiac Dysfunction By Regulating The Mitochondrial Acetylome And Alterations Of The Cardiac Lipidome","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"SIRT3; Sirtuin; Cardiac function curve; Pharmacology; Mitochondrion; Cardiac fibrosis; Endocrinology; Chemistry; Internal medicine; Biology; Acetylation; Biochemistry; Medicine; Fibrosis; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483006,0.0005769606,0.0005701538,0.000254074,0.0002177596,0.0003412171,0.0003884321,0.0005245846,0.007628979],"category_scores_gemma":[0.0001136165,0.0001722676,0.0003561438,0.000196925,0.0004510023,0.0003479114,0.0002003878,0.001593543,0.001371858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096159,"about_ca_system_score_gemma":0.0004050004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958927,"about_ca_topic_score_gemma":0.0009788073,"domain_scores_codex":[0.9998567,0.00001819513,0.00001387861,0.00003572879,0.00003328476,0.00004220649],"domain_scores_gemma":[0.9998927,0.000006414693,0.00003335088,0.00001074033,0.00001058048,0.00004609089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004031053,0.0004782479,0.0003404458,0.0001384801,0.00003601607,0.0001124888,0.00002717827,0.0001038574,0.9873899,0.0002095388,0.0009129337,0.006219824],"study_design_scores_gemma":[0.001054169,0.007292274,0.009212296,0.00004444542,0.0001224334,0.0005486477,0.0001054586,0.001386352,0.9707561,0.0002505883,0.009210363,0.00001698029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809257,0.00321049,0.005317928,0.001291158,0.0004796064,0.0001465122,0.003273569,0.0008167152,0.004538415],"genre_scores_gemma":[0.9810724,0.001345523,0.002452946,0.000456795,0.00008412405,0.0001730321,0.002363335,0.000111908,0.01193998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007628979,"threshold_uncertainty_score":0.02552146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06650778107713613,"score_gpt":0.3749580853143403,"score_spread":0.3084503042372042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}