{"id":"W3215368970","doi":"10.1161/res.129.suppl_1.p425","title":"Abstract P425: Sirtuin 3 Attenuates Doxorubicin Induced Cardiac Dysfunction By Regulating The Mitochondrial Acetylome And Alterations Of The Cardiac Lipidome","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"SIRT3; Sirtuin; Cardiac function curve; Pharmacology; Mitochondrion; Cardiac fibrosis; Endocrinology; Chemistry; Internal medicine; Biology; Acetylation; Biochemistry; Medicine; Fibrosis; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005825677,0.0001018095,0.0002324177,0.00007827382,0.0003989448,0.00005212018,0.00006524113,0.0001054802,0.0001636417],"category_scores_gemma":[0.0002926451,0.00006763228,0.0001281389,0.0005574188,0.0001568227,0.00009117553,0.00007231819,0.000387265,0.000009201382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355373,"about_ca_system_score_gemma":0.0002520375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000308425,"about_ca_topic_score_gemma":0.00003343543,"domain_scores_codex":[0.998289,0.0004255579,0.0002637742,0.0002672217,0.000520832,0.0002336031],"domain_scores_gemma":[0.998443,0.0006147075,0.0000809399,0.0003479341,0.0004399325,0.00007348644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007790365,0.00006587844,0.04294548,0.00004643095,0.0001623453,0.000001068634,0.0006063998,0.0001048958,0.9456086,0.0001161954,0.005855421,0.004409407],"study_design_scores_gemma":[0.001815099,0.0001120033,0.8264344,0.00008724332,0.0001888206,0.000007771192,0.0006678467,0.000587636,0.1641812,0.0002595494,0.005547427,0.000110931],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878443,0.001154846,0.000009207593,0.008472619,0.0008087396,0.0007657352,0.00003680614,0.00001466442,0.0008930262],"genre_scores_gemma":[0.9977602,0.0001075874,0.00002077333,0.00008741146,0.0007542672,0.00008748791,0.0001129676,0.00001567821,0.001053608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7834889,"threshold_uncertainty_score":0.3068401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06650778107713613,"score_gpt":0.3749580853143403,"score_spread":0.3084503042372042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}