{"id":"W3215372888","doi":"10.1139/cjpp-2021-0458","title":"Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K<sup>+</sup> channel pathway","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glibenclamide; Apamin; Chemistry; Pharmacology; Citral; Channel blocker; Capsazepine; Potassium channel blocker; Charybdotoxin; Soluble guanylyl cyclase; Potassium channel; Opioidergic; (+)-Naloxone; Tetraethylammonium; Nitric oxide; Nociception; Opioid; Receptor; Endocrinology; Transient receptor potential channel; Medicine; Biochemistry; TRPV1; Potassium; Calcium","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156986,0.0005197057,0.0004471366,0.000234249,0.0001391091,0.0001589831,0.0003126471,0.0003818375,0.001366232],"category_scores_gemma":[0.0002061571,0.0001989613,0.0003308869,0.0001277159,0.0002729628,0.0003862556,0.000207165,0.0007533668,0.0001692887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001478915,"about_ca_system_score_gemma":0.0002903377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004185835,"about_ca_topic_score_gemma":0.001350201,"domain_scores_codex":[0.9998847,0.00002373933,0.00001212937,0.00001343898,0.00002442399,0.00004154245],"domain_scores_gemma":[0.9998362,0.00002610869,0.00005079666,0.00001240339,0.00001614819,0.00005834456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003905642,0.0006312883,0.0005408222,0.0002859494,0.00003623009,0.0001625638,0.00004160735,0.0000811951,0.9883156,0.00009670614,0.0000824927,0.005819922],"study_design_scores_gemma":[0.0006379155,0.01753991,0.02149028,0.00006044013,0.000132872,0.0005333121,0.0001287842,0.001241818,0.9560434,0.00007160884,0.002097939,0.00002176401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949716,0.003534056,0.0004131114,0.0001252839,0.00003135708,0.00003426934,0.00007574608,0.00003126114,0.0007833064],"genre_scores_gemma":[0.9932957,0.003709562,0.001181376,0.0001257161,0.00003966074,0.00006162632,0.0002049083,0.000007780663,0.00137369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366232,"threshold_uncertainty_score":0.004570484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008164324309405467,"score_gpt":0.2498360757047802,"score_spread":0.2416717513953748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}