{"id":"W3215379357","doi":"10.7554/elife.64695.sa2","title":"Author response: A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Ataxia-telangiectasia; Ataxia; Null allele; Neuroscience; Nonsense mutation; Mutation; Cerebellar ataxia; Atrophy; Biology; Missense mutation; Genetics; Phenotype; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360127,0.0008559044,0.0005157961,0.0008055458,0.0004925712,0.0006924833,0.00102539,0.002525261,0.09405029],"category_scores_gemma":[0.002401351,0.0003228961,0.0006254269,0.0002580177,0.0003169789,0.0005812013,0.0004517845,0.001530802,0.02784596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472359,"about_ca_system_score_gemma":0.0005581399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004336778,"about_ca_topic_score_gemma":0.001213013,"domain_scores_codex":[0.9991986,0.0001525487,0.00009318563,0.0001408376,0.0003436286,0.00007118213],"domain_scores_gemma":[0.9981863,0.0004580909,0.0001854892,0.0001244447,0.0006995992,0.0003461135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009228453,0.00015921,0.0008041269,0.0003564498,0.00002888263,0.001784213,0.00005280825,0.0001592147,0.02476666,0.001227875,0.9369236,0.03281396],"study_design_scores_gemma":[0.0004421044,0.0005222021,0.002522991,0.0001787194,0.00005824833,0.003632298,0.0001729885,0.0008942093,0.03238984,0.001718236,0.9573972,0.00007098504],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.06585754,0.007588814,0.05459163,0.2894799,0.327114,0.004129165,0.03071706,0.02145103,0.1990709],"genre_scores_gemma":[0.09006082,0.004097408,0.03127501,0.06147187,0.01912764,0.001572126,0.01074411,0.001624627,0.7800263],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.09405029,"threshold_uncertainty_score":0.3146296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113850580711405,"score_gpt":0.3728688596249153,"score_spread":0.2614838015537748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}