{"id":"W3215388564","doi":"10.1038/s41467-022-34382-7","title":"Computationally designed GPCR quaternary structures bias signaling pathway activation","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; Université de Montréal; Fondation pour la Recherche Médicale; Swiss Cancer Research Foundation; European Commission; École Polytechnique Fédérale de Lausanne; Fonds Wetenschappelijk Onderzoek; Ludwig Institute for Cancer Research; Fonds De La Recherche Scientifique - FNRS; Fonds National de la Recherche Luxembourg; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Canadian Institutes of Health Research; National Science Foundation","keywords":"Protein quaternary structure; G protein-coupled receptor; Receptor; Signal transduction; Chemokine receptor; Cell biology; Biology; Chemistry; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003068843,0.0005892992,0.0006522512,0.0003145051,0.0003827483,0.0005573095,0.0004991288,0.0005954019,0.001870449],"category_scores_gemma":[0.0005337941,0.0003136978,0.0004267081,0.0002258322,0.0003107224,0.000435456,0.0002835715,0.0005613321,0.0002341528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007874097,"about_ca_system_score_gemma":0.001350282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002456637,"about_ca_topic_score_gemma":0.00515439,"domain_scores_codex":[0.9999094,0.00002131595,0.000004239735,0.00001949478,0.00001795757,0.00002750655],"domain_scores_gemma":[0.9998609,0.0000652048,0.00001805609,0.00001021673,0.0000294556,0.00001628502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000279416,0.0001900445,0.002614094,0.0001735344,0.00004450713,0.0003029269,0.00005010203,0.952138,0.02493539,0.00886979,0.0008284408,0.009573711],"study_design_scores_gemma":[0.00005682162,0.0001195774,0.0002801118,0.000006129013,0.00002445003,0.00002339736,0.00003284991,0.9927737,0.00446871,0.001550227,0.0006562311,0.000007791517],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9415522,0.0003438537,0.04750685,0.0002817832,0.00004645471,0.00008486087,0.0004905082,0.0005205875,0.009172818],"genre_scores_gemma":[0.9677036,0.0002818688,0.02986876,0.0001072822,0.000009687796,0.0001297071,0.0006771568,0.00007931135,0.001142636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002456637,"threshold_uncertainty_score":0.006257296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03080449267150433,"score_gpt":0.2849695401246607,"score_spread":0.2541650474531564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}