{"id":"W3215398375","doi":"10.1093/neuonc/noab196.021","title":"EPCO-22. INHERITED POLYMORPHISM IN CHROMOSOME 8Q24 COOPERATES WITH MUTANT IDH1, Trp53 AND ATRX LOSS TO INDUCE LOW-GRADE GLIOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"ATRX; Biology; Allele; Genetics; CDKN2A; Locus (genetics); Glioma; Cancer research; Penetrance; Gene; Single-nucleotide polymorphism; Genotype; Mutant; IDH1; Carcinogenesis; Mutation; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387795,0.000570435,0.0003151658,0.0005875525,0.0001655719,0.0001979314,0.0002467005,0.000400562,0.003669147],"category_scores_gemma":[0.0001397445,0.0001461919,0.0003866219,0.0002449658,0.0002663232,0.00005496879,0.0002928994,0.0006657975,0.0006560964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357383,"about_ca_system_score_gemma":0.000157141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008778856,"about_ca_topic_score_gemma":0.00123112,"domain_scores_codex":[0.9998492,0.00002961999,0.00001441429,0.00003709138,0.00003520793,0.00003446201],"domain_scores_gemma":[0.9998093,0.00003126967,0.00006067475,0.00002017132,0.000007275268,0.0000712874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002906802,0.00017787,0.001494294,0.00003241171,0.00003863911,0.001912154,0.00001677848,0.0001388322,0.9931569,0.0002048976,0.0002643752,0.002272343],"study_design_scores_gemma":[0.0004541696,0.00301987,0.103913,0.00004696671,0.0001867849,0.02370339,0.0001390467,0.005039514,0.8515344,0.0004412122,0.01148587,0.0000357371],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948319,0.0003954922,0.001731733,0.0001575152,0.00005368829,0.00006829916,0.0009751491,0.0002124983,0.001573655],"genre_scores_gemma":[0.9964455,0.0001583853,0.0005623641,0.00006831795,0.000009971292,0.00004378248,0.0005816356,0.00004275322,0.002087331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003669147,"threshold_uncertainty_score":0.0122745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805379750293446,"score_gpt":0.2826563719139711,"score_spread":0.2646025744110366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}