{"id":"W3215404402","doi":"10.1182/blood-2021-147946","title":"A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in Low Risk (LR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs): A Report from Children's Oncology Group Study AALL1331","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Chemotherapy; Blinatumomab; Mitoxantrone; Acute lymphocytic leukemia; Internal medicine; Leukemia; Maintenance therapy; Minimal residual disease; Surgery; Oncology; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001710938,0.0005376731,0.002471022,0.0006673879,0.00006560722,0.00002807666,0.0002913167,0.0005071653,0.00008521439],"category_scores_gemma":[0.001818468,0.0004700787,0.0003644078,0.000932565,0.0003829248,0.0001774944,0.0001744806,0.0007931641,0.000004356552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008838743,"about_ca_system_score_gemma":0.002250344,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01258338,"about_ca_topic_score_gemma":0.0007689286,"domain_scores_codex":[0.994067,0.001075023,0.00205588,0.001180582,0.001015226,0.0006063512],"domain_scores_gemma":[0.9966838,0.0006424515,0.00106831,0.0009532311,0.0003928932,0.0002592704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8137353,0.02705537,0.1415766,0.00007140636,0.003276366,0.002750491,0.002965174,0.000009063329,0.005329539,0.000002699949,0.0000250611,0.00320297],"study_design_scores_gemma":[0.7286234,0.007510304,0.2537397,0.0006868787,0.001004078,0.001818683,0.0002466374,0.0003105871,0.005755968,0.0000329354,0.000001820977,0.0002690913],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921595,0.0006281206,0.00002727391,0.0001946719,0.0002266086,0.00654457,0.0001340411,0.00004796683,0.00003725449],"genre_scores_gemma":[0.9947981,0.003520891,0.0003821115,0.0001057592,0.0002882905,0.0002881997,0.0004879336,0.00009609037,0.00003265534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1121631,"threshold_uncertainty_score":0.9997751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007673334348850686,"score_gpt":0.2852279301080738,"score_spread":0.2775545957592231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}