{"id":"W3215404402","doi":"10.1182/blood-2021-147946","title":"A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in Low Risk (LR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs): A Report from Children's Oncology Group Study AALL1331","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Chemotherapy; Blinatumomab; Mitoxantrone; Acute lymphocytic leukemia; Internal medicine; Leukemia; Maintenance therapy; Minimal residual disease; Surgery; Oncology; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00221808,0.001916726,0.003148078,0.0005060054,0.0004882726,0.001323891,0.001547389,0.001834353,0.006942441],"category_scores_gemma":[0.001518911,0.000656223,0.001967278,0.0004588956,0.001430796,0.001139147,0.0005119984,0.004670083,0.001311071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00104853,"about_ca_system_score_gemma":0.00155131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409149,"about_ca_topic_score_gemma":0.003327069,"domain_scores_codex":[0.9991353,0.0005231012,0.00003152956,0.0001178421,0.00004254877,0.0001497401],"domain_scores_gemma":[0.9984633,0.0004913529,0.0002952728,0.0001427926,0.00005771523,0.0005495765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9829641,0.008909579,0.0003203232,0.0001422772,0.0002642234,0.00001979454,0.00004038441,0.0002099369,0.001411419,0.00007812261,0.0003348913,0.005304992],"study_design_scores_gemma":[0.9005768,0.09705542,0.001118268,0.00001647055,0.0002036849,0.00001979283,0.00002595155,0.0002937292,0.0002956295,0.0001041033,0.0002802759,0.000009796099],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924055,0.001543103,0.0003289024,0.0004811366,0.0004879461,0.002675529,0.000677191,0.000088974,0.001311779],"genre_scores_gemma":[0.9869467,0.001280346,0.001156789,0.0009596497,0.0004711733,0.005057144,0.001034165,0.00003579327,0.003058113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006942441,"threshold_uncertainty_score":0.02322483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007673334348850686,"score_gpt":0.2852279301080738,"score_spread":0.2775545957592231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}