{"id":"W3215424220","doi":"10.3389/ftox.2021.709747","title":"Using Live Imaging and FUCCI Embryonic Stem Cells to Rank DevTox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude","year":2021,"lang":"en","type":"article","venue":"Frontiers in Toxicology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Division of Materials Research; National Institute of Environmental Health Sciences; National Institutes of Health; Texas Emerging Technology Fund","keywords":"Toxicant; Embryonic stem cell; Cell cycle; Chemistry; Cell cycle checkpoint; Induced pluripotent stem cell; Andrology; Toxicity; Apoptosis; Cell biology; Biology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003697228,0.0008858994,0.0003494213,0.0004114541,0.0003675673,0.00055669,0.0003121286,0.000618918,0.003768579],"category_scores_gemma":[0.0001731409,0.0002678531,0.0003549432,0.0004357188,0.0003897911,0.0003940651,0.0003246141,0.001367589,0.0007441913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005442483,"about_ca_system_score_gemma":0.0004231171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395251,"about_ca_topic_score_gemma":0.002454817,"domain_scores_codex":[0.9995702,0.00004870511,0.00003483066,0.0001512007,0.0001220444,0.00007305363],"domain_scores_gemma":[0.9998338,0.00003778199,0.00004009364,0.00001861543,0.00004069261,0.00002901316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007649942,0.00002091158,0.0002300784,0.00008790983,0.000007421365,0.00004605748,0.00003866994,0.000073612,0.9968296,0.0002042192,0.000111053,0.002273982],"study_design_scores_gemma":[0.000004719573,0.00009712084,0.002228665,0.000007078367,0.000008397828,0.0001281512,0.00002761787,0.0007434422,0.9943416,0.00004928613,0.002358923,0.000004992055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9059688,0.005107624,0.07051722,0.0005406797,0.000257194,0.0001581194,0.002610277,0.0009417183,0.01389844],"genre_scores_gemma":[0.8773037,0.004893512,0.08062215,0.0004161084,0.00005411734,0.0005507859,0.005110098,0.0003716468,0.03067793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003768579,"threshold_uncertainty_score":0.01260722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324061309472509,"score_gpt":0.25220720464377,"score_spread":0.2389665915490449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}