{"id":"W3215478730","doi":"10.1002/ejoc.202101170","title":"Improved Synthesis of D‐Isoglutamine: Rapid Access to Desmuramyl Analogues of Muramyl Dipeptide for the Activation of Intracellular NOD2 Receptor and Vaccine Adjuvant Applications","year":2021,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Muramyl dipeptide; Chemistry; NOD2; Adjuvant; Peptidoglycan; Immunoadjuvant; Stereochemistry; Immunogenicity; Dipeptide; Combinatorial chemistry; Biochemistry; Innate immune system; Immune system; Receptor; Amino acid; In vitro; Enzyme; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314561,0.0005331592,0.0002788523,0.0001784632,0.0001057841,0.0001496592,0.0003751256,0.0003104462,0.001047917],"category_scores_gemma":[0.0001748225,0.0001409948,0.0002179214,0.0002486344,0.0001256306,0.0002904437,0.0003629482,0.0004669464,0.0006549372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016586,"about_ca_system_score_gemma":0.0002469123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910992,"about_ca_topic_score_gemma":0.0002848605,"domain_scores_codex":[0.9998952,0.00002615222,0.0000111846,0.00001735844,0.00001742294,0.00003263028],"domain_scores_gemma":[0.9999248,0.000006829921,0.00002363783,0.0000104695,0.00001244941,0.00002195881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001548946,0.0001073246,0.0001030025,0.0003128426,0.00001566871,0.0005037486,0.00007217413,0.0008907791,0.985146,0.0008637219,0.0002547893,0.01157505],"study_design_scores_gemma":[0.0001505607,0.00202928,0.0008740362,0.00002549824,0.00003339231,0.0006964475,0.00004538647,0.00202018,0.9778168,0.0002931952,0.01597465,0.00004056098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9159321,0.005896955,0.06412849,0.0003401769,0.0002240607,0.00046939,0.001060263,0.0002655533,0.01168308],"genre_scores_gemma":[0.9670433,0.002797553,0.02696735,0.0001055783,0.00002757637,0.0001649817,0.0004961104,0.00004303999,0.00235441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047917,"threshold_uncertainty_score":0.003505588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427152154128795,"score_gpt":0.2509694243910356,"score_spread":0.2366979028497477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}