{"id":"W3215570794","doi":"10.1161/circ.144.suppl_1.13273","title":"Abstract 13273: Late Senolytic Therapy Improves Cerebrovascular Endothelial Function but Not Cognition in Middle-Aged Severely Atherosclerotic Mice","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Medicine; Cerebral circulation; Cognitive decline; Cardiology; Internal medicine; Endothelium; Endothelial dysfunction; Pathology; Endocrinology; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861434,0.0009252848,0.0007537715,0.0004657546,0.0002537298,0.0003539793,0.0003412321,0.0006198629,0.003423005],"category_scores_gemma":[0.0001113216,0.0002230431,0.0003390675,0.0001896923,0.0003782903,0.0002816436,0.0002049578,0.001264083,0.0007211727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508395,"about_ca_system_score_gemma":0.0005064409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009882456,"about_ca_topic_score_gemma":0.001834578,"domain_scores_codex":[0.999856,0.00001795716,0.00001252178,0.00002019709,0.00003175473,0.00006164146],"domain_scores_gemma":[0.9998074,0.00001065629,0.00004694563,0.000017737,0.00002133785,0.00009590655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00290192,0.0007105847,0.0002493235,0.00008746978,0.00002859008,0.0001110955,0.00002921595,0.00008303458,0.9905967,0.0001118716,0.0002926005,0.004797607],"study_design_scores_gemma":[0.001157099,0.02213163,0.01637646,0.00007905278,0.0001608588,0.0004991798,0.0001261091,0.001272927,0.9531805,0.0002228371,0.004760625,0.00003265913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952039,0.001014717,0.0008818509,0.0001734222,0.00006956684,0.00004477178,0.0005797743,0.0002471327,0.001785005],"genre_scores_gemma":[0.9856483,0.001662922,0.00162797,0.0002537697,0.00005778472,0.00017061,0.001290587,0.0000521596,0.009236002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003423005,"threshold_uncertainty_score":0.01145107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721157895830987,"score_gpt":0.2104924079784105,"score_spread":0.1832808290201006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}