{"id":"W3215584091","doi":"10.1016/j.bbrep.2021.101174","title":"Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brock University; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Roswell Park Cancer Institute; National Cancer Institute; National Institutes of Health; American Cancer Society","keywords":"Survivin; Microvesicles; Cell biology; Biology; Extracellular; Apoptosis; Chemistry; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379669,0.0002117164,0.0001904951,0.00001775158,0.00008955123,0.00006767725,0.000050673,0.000133898,0.000007359124],"category_scores_gemma":[0.00003245144,0.0001489117,0.00003063662,0.0001602058,0.00007715938,0.000008049552,0.0001378884,0.0001113446,4.807411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009152267,"about_ca_system_score_gemma":0.00007601443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003219382,"about_ca_topic_score_gemma":0.00006036473,"domain_scores_codex":[0.9988758,0.00002348529,0.0002349366,0.0005405459,0.0001259152,0.0001993311],"domain_scores_gemma":[0.9993013,0.00001303057,0.0001383631,0.0003311751,0.00009600271,0.0001201934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008613976,0.00005569249,0.002922978,0.0001240335,0.00002205826,0.0002485146,0.00004605708,0.00003105474,0.9953679,0.000006864195,0.00006842407,0.001020274],"study_design_scores_gemma":[0.000315274,0.0001036809,0.002183578,0.00008505697,0.00002447148,0.0006951491,0.0002557227,0.0002581011,0.9902347,0.00003583627,0.005553597,0.0002548203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970217,0.002288055,0.0001564832,0.0001475378,0.00007661928,0.0001654415,0.00001245257,0.000007735706,0.0001240253],"genre_scores_gemma":[0.9975237,0.0004775327,0.0003164046,0.00009730381,0.0001093333,0.00001105876,0.0001827582,0.00001987452,0.001262068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005485173,"threshold_uncertainty_score":0.6072441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004467076239328815,"score_gpt":0.1928310138230374,"score_spread":0.1883639375837086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}