{"id":"W3215602595","doi":"10.1158/1538-7445.am2019-1011","title":"Abstract 1011: Prolactin-induced EDD E3 ubiquitin ligase regulates pro/anti-apoptotic gene expression, and stimulates TORC1 signaling and drug resistance in breast cancer cells","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Biology; Ubiquitin ligase; Apoptosis; Cell cycle; Cancer cell; Transfection; Cancer research; Cell biology; Molecular biology; Ubiquitin; Cancer; Cell culture; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006417734,0.0002160122,0.0002446136,0.0001521447,0.0001334481,0.0001992196,0.00009286647,0.0001594501,0.001961879],"category_scores_gemma":[0.00005061531,0.0001040085,0.0002590486,0.0001874323,0.0001163548,0.00007532826,0.0001443939,0.0003271289,0.0005322527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959848,"about_ca_system_score_gemma":0.0001574261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007337816,"about_ca_topic_score_gemma":0.0007956685,"domain_scores_codex":[0.9998831,0.00001323879,0.00001131563,0.00002620268,0.00002898688,0.00003724858],"domain_scores_gemma":[0.9999617,0.000004589574,0.000008598502,0.00000434455,0.000005807123,0.00001487059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002548746,0.00002985988,0.0003481952,0.0000349921,0.000005533108,0.00004284269,0.000005495628,0.00002108305,0.9982471,0.00002172889,0.00008363166,0.0009047152],"study_design_scores_gemma":[0.00003644532,0.0003279572,0.018799,0.000004204509,0.000020418,0.0003579094,0.00003442154,0.0006882006,0.9770359,0.00001703102,0.002674386,0.000004110317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937918,0.001934767,0.001264716,0.0001247557,0.00003546691,0.00001926176,0.001246992,0.00006976504,0.001512665],"genre_scores_gemma":[0.9918875,0.0005733963,0.001065983,0.0000865699,0.000006623535,0.00003016794,0.002247153,0.00001790776,0.004084652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961879,"threshold_uncertainty_score":0.006563187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785394132044355,"score_gpt":0.3190318135144298,"score_spread":0.2911778721939862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}