{"id":"W3215641558","doi":"10.1182/blood-2021-153262","title":"Tisagenlecleucel Therapy Is Safe and Effective for Children with Down Syndrome with ALL in First Relapse","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Centre Hospitalier Universitaire Sainte-Justine; London Health Sciences Centre; Montreal Children's Hospital; Izaak Walton Killam Health Centre; Hospital for Sick Children","funders":"","keywords":"Medicine; Population; Blinatumomab; Hematopoietic stem cell transplantation; Pediatrics; Cumulative incidence; Chimeric antigen receptor; Transplantation; Cytokine release syndrome; Incidence (geometry); Internal medicine; Oncology; Leukemia; Lymphoblastic Leukemia; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009074847,0.0001139755,0.0002701274,0.0001633298,0.0002121261,0.000237544,0.0001605797,0.000121566,0.001169876],"category_scores_gemma":[0.0003645183,0.00003675327,0.0001719927,0.0001730649,0.0001566831,0.00008191675,0.0001204904,0.0003334221,0.0001314641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000972459,"about_ca_system_score_gemma":0.001320689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01657614,"about_ca_topic_score_gemma":0.05181792,"domain_scores_codex":[0.9999282,0.000009343453,0.000006201743,0.000009393181,0.00002350537,0.00002332861],"domain_scores_gemma":[0.9998234,0.00002673896,0.00005204109,0.000007983896,0.00001819595,0.00007161199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.005333168,0.001224339,0.4733813,0.0007301313,0.000269365,0.01299183,0.0007965615,0.000981936,0.03020784,0.0005414611,0.01075976,0.4627822],"study_design_scores_gemma":[0.0008617133,0.006771646,0.9329396,0.000240493,0.0002338281,0.02247913,0.0003644291,0.0007375455,0.008792548,0.0001470404,0.02641019,0.00002163774],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896109,0.004087489,0.0002912244,0.0003272486,0.00002239524,0.00006916757,0.0005790325,0.00007122571,0.004941375],"genre_scores_gemma":[0.9976538,0.0008220774,0.0003162986,0.0001250011,0.000009336622,0.00001448391,0.0004485431,0.000004923852,0.0006055182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01657614,"threshold_uncertainty_score":0.03295934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517104997503947,"score_gpt":0.2743083153968002,"score_spread":0.2591372654217607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}