{"id":"W3215668940","doi":"10.1182/blood-2021-146021","title":"Health-Related Quality of Life Following Valoctocogene Roxaparvovec Gene Therapy for Severe Hemophilia A in the Phase 3 Trial GENEr8-1","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Haemophilia; Quality of life (healthcare); Worry; Haemophilia A; Internal medicine; Physical therapy; Pediatrics; Anxiety; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001972329,0.0003334387,0.000790688,0.0001547402,0.0001680032,0.0005851162,0.0002549252,0.0003790646,0.002138274],"category_scores_gemma":[0.001291907,0.0001393401,0.001079655,0.0002315305,0.0002040562,0.0003278058,0.0003083345,0.0009838593,0.0001898254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659753,"about_ca_system_score_gemma":0.0003709925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000293351,"about_ca_topic_score_gemma":0.000609156,"domain_scores_codex":[0.9991824,0.0004737478,0.00004005033,0.00008539711,0.0001051962,0.0001132561],"domain_scores_gemma":[0.9993299,0.0001588934,0.0002406804,0.00004789754,0.00007125444,0.0001513816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7715579,0.01276398,0.105667,0.0007599324,0.004454085,0.0001005947,0.0002436857,0.001792781,0.01157882,0.0002582908,0.003068424,0.08775456],"study_design_scores_gemma":[0.07540344,0.3419985,0.5641897,0.0001411586,0.004367709,0.0003131654,0.0002214055,0.002297485,0.006289783,0.0003517298,0.004352317,0.00007361465],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967133,0.00118706,0.0001516843,0.0001008616,0.00002614344,0.0002057825,0.0009495695,0.000007213682,0.000658454],"genre_scores_gemma":[0.9974989,0.0002867252,0.0001923899,0.000101502,0.00003048284,0.0003479667,0.001091661,0.000003018857,0.0004473898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138274,"threshold_uncertainty_score":0.01043081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057252454380711,"score_gpt":0.4021472116283459,"score_spread":0.2964219661902748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}