{"id":"W3215679919","doi":"10.1093/neuonc/noaa222.407","title":"LGG-25. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; BC Children's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Calgary; McGill University; University of British Columbia; Hospital for Sick Children; Université de Montréal; Montreal Children's Hospital; Centre hospitalier universitaire de Québec; Dalhousie University; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trametinib; Medicine; Tolerability; Adverse effect; Internal medicine; MAPK/ERK pathway; Oncology; Refractory (planetary science); Gastroenterology; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001447682,0.00159044,0.001343943,0.000506853,0.0003351216,0.0008624776,0.001120085,0.001090093,0.002736081],"category_scores_gemma":[0.0005168575,0.0005128671,0.001085355,0.0004884497,0.0007542673,0.0004826254,0.0002758979,0.002179887,0.0008261533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001924559,"about_ca_system_score_gemma":0.002680416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005334899,"about_ca_topic_score_gemma":0.01755422,"domain_scores_codex":[0.9995759,0.0001900417,0.00001365072,0.00005334681,0.00004255873,0.0001244174],"domain_scores_gemma":[0.9996088,0.00003779965,0.00006479576,0.00002112787,0.00002441153,0.0002429854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4473026,0.1127381,0.0325915,0.001885585,0.002841445,0.001814527,0.0007837697,0.006758686,0.1017022,0.0008387557,0.02023647,0.2705064],"study_design_scores_gemma":[0.4525642,0.48813,0.03937403,0.00008127887,0.000788291,0.001148115,0.0001447058,0.002231187,0.007624278,0.000200026,0.007664893,0.00004888883],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899493,0.002532796,0.0003451402,0.0004870867,0.00006551181,0.002774075,0.001828253,0.0001518931,0.001865885],"genre_scores_gemma":[0.9856053,0.002344232,0.00197956,0.001069356,0.0000773305,0.002564754,0.003963806,0.00003420026,0.002361479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005334899,"threshold_uncertainty_score":0.0139637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519919493666345,"score_gpt":0.2910351558811074,"score_spread":0.2658359609444439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}