{"id":"W3215679919","doi":"10.1093/neuonc/noaa222.407","title":"LGG-25. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; BC Children's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Calgary; McGill University; University of British Columbia; Hospital for Sick Children; Université de Montréal; Montreal Children's Hospital; Centre hospitalier universitaire de Québec; Dalhousie University; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trametinib; Medicine; Tolerability; Adverse effect; Internal medicine; MAPK/ERK pathway; Oncology; Refractory (planetary science); Gastroenterology; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006337011,0.0001762719,0.0005018818,0.00009612233,0.00005142152,0.000004022168,0.0001086342,0.00007814178,0.00002039103],"category_scores_gemma":[0.0001828007,0.00009877753,0.0000838666,0.0005415677,0.00005663533,0.00004121034,0.00002737305,0.0001310152,0.000001021904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004851383,"about_ca_system_score_gemma":0.0001947927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001555023,"about_ca_topic_score_gemma":0.00001341253,"domain_scores_codex":[0.9987186,0.0001116494,0.0003530271,0.0003174312,0.0003099996,0.0001893142],"domain_scores_gemma":[0.9986418,0.0003957949,0.0003949465,0.000258629,0.000197539,0.0001112359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01902487,0.07057668,0.7644215,0.0004216032,0.0005799091,0.0001832753,0.00765674,0.00008392464,0.09739617,0.00008195867,0.001150226,0.0384232],"study_design_scores_gemma":[0.1530947,0.3115439,0.3315,0.00006520461,0.002534909,0.00002934781,0.002141851,0.0001456696,0.193653,0.00001809132,0.004964766,0.0003085367],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953276,0.00001406426,0.00002537798,0.001279164,0.0000763705,0.003098531,0.00005584478,0.00002144179,0.0001016268],"genre_scores_gemma":[0.9989661,0.000003242278,0.0002385462,0.0003561726,0.00008901369,0.0002934013,0.00002199341,0.00003055772,9.551595e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4329214,"threshold_uncertainty_score":0.4028031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519919493666345,"score_gpt":0.2910351558811074,"score_spread":0.2658359609444439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}