{"id":"W3215680736","doi":"10.1161/circ.144.suppl_1.11091","title":"Abstract 11091: Failure of Right Ventricular Adaptation to Pressure Overload Due to a Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; University of Ottawa; Canadian Electricity Association; Ottawa Public Health; Ottawa Hospital; Ottawa Heart Institute; Montreal Heart Institute","funders":"","keywords":"Medicine; Internal medicine; Adenylate kinase; Pressure overload; Pulmonary hypertension; Hypoxia (environmental); Heart failure; Endocrinology; Oxygen; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926813,0.0007805608,0.0005139954,0.0003816668,0.0001768029,0.0002588901,0.0002520483,0.0003155428,0.002708239],"category_scores_gemma":[0.0001463619,0.0002168933,0.0002449025,0.0001604589,0.0007339882,0.0002546806,0.000378176,0.000740234,0.0004323188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319017,"about_ca_system_score_gemma":0.0002207315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004974994,"about_ca_topic_score_gemma":0.0004106313,"domain_scores_codex":[0.9998224,0.00001678759,0.00002064919,0.00005724918,0.00004519662,0.00003772662],"domain_scores_gemma":[0.9997618,0.00002851163,0.00007973904,0.00001858195,0.00001195227,0.00009949108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005129777,0.00004128131,0.001195359,0.00003772334,0.00001006434,0.0002839208,0.00001340949,0.0000336091,0.9965953,0.0000514956,0.00005963923,0.001165107],"study_design_scores_gemma":[0.0001866915,0.003575897,0.1645992,0.00003431503,0.0001007501,0.008348281,0.0001969908,0.001786474,0.8185031,0.0002769192,0.002357741,0.00003369309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976299,0.0003332547,0.001059641,0.0001012597,0.00002404379,0.00001444126,0.0004562003,0.00004389095,0.0003373721],"genre_scores_gemma":[0.9963043,0.0002819795,0.001025487,0.00007734326,0.00002688281,0.00003336068,0.0007372011,0.00002652657,0.001486962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002708239,"threshold_uncertainty_score":0.009059906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009967072536843419,"score_gpt":0.2293449242954606,"score_spread":0.2193778517586171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}