{"id":"W3215688055","doi":"10.1161/circ.144.suppl_1.13094","title":"Abstract 13094: Pharmacokinetics and Therapeutic Efficacy of Drpitor1a, a Novel Dynamin-Related Protein 1 Inhibitor, in a Preclinical Model of Pulmonary Arterial Hypertension","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Queen's University","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacology; Pulmonary hypertension; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002376509,0.0004061222,0.0006359196,0.0002887482,0.0001471346,0.0002548606,0.0003442777,0.0003766234,0.001754524],"category_scores_gemma":[0.000221583,0.0001781014,0.0002728015,0.0001901283,0.0002893404,0.0004241248,0.0001105529,0.00104018,0.0004510612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711404,"about_ca_system_score_gemma":0.0004682368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005169462,"about_ca_topic_score_gemma":0.0007013575,"domain_scores_codex":[0.9998533,0.00002871613,0.00001010377,0.00002969783,0.00003497912,0.00004331034],"domain_scores_gemma":[0.9998098,0.00002867006,0.00006305461,0.0000214,0.00001913666,0.00005786818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01155852,0.002055267,0.000516772,0.0001392014,0.00005210796,0.0001009751,0.0000461739,0.0003755353,0.9681389,0.0001003446,0.0005576676,0.01635857],"study_design_scores_gemma":[0.001792666,0.0693042,0.009136993,0.00001808849,0.0001485514,0.000475147,0.0000436187,0.002513595,0.9124195,0.00006684665,0.004051449,0.00002937097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995452,0.001480435,0.0009480047,0.0001474418,0.00004139964,0.00009735446,0.0008802921,0.0001445162,0.000808578],"genre_scores_gemma":[0.9908184,0.001428264,0.00202748,0.00009284612,0.00005535415,0.0002060231,0.001784868,0.00003693199,0.003549656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001754524,"threshold_uncertainty_score":0.005869448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03542023413484957,"score_gpt":0.2844166526593928,"score_spread":0.2489964185245432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}