{"id":"W3215701750","doi":"10.1007/s10549-021-06450-x","title":"Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial","year":2021,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Medicine; Breast cancer; Internal medicine; Hazard ratio; Placebo; Paclitaxel; Taxane; Oncology; Clinical endpoint; Chemotherapy; Cancer; Gastroenterology; Randomized controlled trial; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289149,0.001228844,0.001444124,0.0003509866,0.0002517716,0.0008171721,0.0005523628,0.0008124324,0.005247521],"category_scores_gemma":[0.001010301,0.0004484836,0.001884481,0.0003713189,0.0005080112,0.0005472132,0.0002939471,0.002323678,0.0006862516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006830498,"about_ca_system_score_gemma":0.001030581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121133,"about_ca_topic_score_gemma":0.002734069,"domain_scores_codex":[0.999671,0.0001790509,0.00001805001,0.00004898235,0.00003159512,0.00005146865],"domain_scores_gemma":[0.9996083,0.0001003736,0.0001058688,0.00003151201,0.00002394899,0.0001300108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9585372,0.005095006,0.001487941,0.000705317,0.001301659,0.00005056186,0.00005658416,0.0007046618,0.003857798,0.0001697019,0.003082417,0.02495125],"study_design_scores_gemma":[0.9361362,0.05526651,0.004282299,0.00006094464,0.001103838,0.0000876406,0.00002215931,0.0005475454,0.0006515201,0.0002332015,0.001592915,0.00001522457],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788069,0.006685445,0.0005904328,0.0007265644,0.0003045186,0.003573339,0.003399485,0.0001174695,0.005795735],"genre_scores_gemma":[0.9818764,0.004812201,0.001185902,0.001146228,0.0004477353,0.00346636,0.003966964,0.0000353554,0.003062987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005247521,"threshold_uncertainty_score":0.01755476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520119051657982,"score_gpt":0.3610917612727934,"score_spread":0.3258905707562136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}